Green Chemistry Approaches in Drug Development
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| Natura: | Recurso digital |
| Lingua: | inglese |
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Zenodo
2025
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| _version_ | 1866902127654207488 |
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| author | Milap Patel |
| author_facet | Milap Patel |
| contents | <p><span lang="EN-IN">Green chemistry, alternatively known as sustainable chemistry, represents a transformative approach aimed at reducing the environmental burden associated with conventional chemical practices. Within the pharmaceutical industry, traditional drug development processes are frequently resource-intensive and produce considerable hazardous waste. Green chemistry offers a sustainable alternative by re-engineering synthetic methodologies, improving atom economy, utilizing renewable feedstocks, and integrating safer solvents and reagents. This chapter delves into the integration of the 12 Principles of Green Chemistry into the drug discovery and development pipeline. From lead identification and optimization to process scale-up and formulation, each stage can be enhanced for greater sustainability. Notably, the replacement of toxic solvents with eco-friendly alternatives, implementation of biocatalysis, and adoption of energy-efficient technologies like microwave-assisted synthesis and continuous flow chemistry have become increasingly mainstream. Green metrics such as the E-factor and process mass intensity (PMI) allow for quantification and optimization of process greenness. Real-world case studies, including Merck’s production of sitagliptin and Pfizer’s optimized sertraline synthesis, serve as benchmarks for successful green chemistry adoption. Moreover, regulatory bodies such as the FDA and EMA are encouraging these initiatives through Quality by Design (QbD) and lifecycle management frameworks. Looking ahead, technological advances such as artificial intelligence, machine learning, and digital twin modeling are poised to further catalyze the adoption of green chemistry. This chapter presents a comprehensive and practical exploration of how green chemistry is reshaping pharmaceutical innovation towards a more sustainable and efficient future.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_15711837 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Green Chemistry Approaches in Drug Development Milap Patel Green Chemistry, Sustainable Chemistry, Pharmaceutical Industry, Drug Development, 12 Principles of Green Chemistry, Atom Economy. <p><span lang="EN-IN">Green chemistry, alternatively known as sustainable chemistry, represents a transformative approach aimed at reducing the environmental burden associated with conventional chemical practices. Within the pharmaceutical industry, traditional drug development processes are frequently resource-intensive and produce considerable hazardous waste. Green chemistry offers a sustainable alternative by re-engineering synthetic methodologies, improving atom economy, utilizing renewable feedstocks, and integrating safer solvents and reagents. This chapter delves into the integration of the 12 Principles of Green Chemistry into the drug discovery and development pipeline. From lead identification and optimization to process scale-up and formulation, each stage can be enhanced for greater sustainability. Notably, the replacement of toxic solvents with eco-friendly alternatives, implementation of biocatalysis, and adoption of energy-efficient technologies like microwave-assisted synthesis and continuous flow chemistry have become increasingly mainstream. Green metrics such as the E-factor and process mass intensity (PMI) allow for quantification and optimization of process greenness. Real-world case studies, including Merck’s production of sitagliptin and Pfizer’s optimized sertraline synthesis, serve as benchmarks for successful green chemistry adoption. Moreover, regulatory bodies such as the FDA and EMA are encouraging these initiatives through Quality by Design (QbD) and lifecycle management frameworks. Looking ahead, technological advances such as artificial intelligence, machine learning, and digital twin modeling are poised to further catalyze the adoption of green chemistry. This chapter presents a comprehensive and practical exploration of how green chemistry is reshaping pharmaceutical innovation towards a more sustainable and efficient future.</span></p> |
| title | Green Chemistry Approaches in Drug Development |
| topic | Green Chemistry, Sustainable Chemistry, Pharmaceutical Industry, Drug Development, 12 Principles of Green Chemistry, Atom Economy. |
| url | https://doi.org/10.5281/zenodo.15711837 |