Synergistic Effects of Pharmacological, Environmental, and Transcranial Direct Current Stimulation Interventions on Depression-Like Behaviours in Rats Under Social and Movement Restriction - Figure 4
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2025
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| _version_ | 1866901648384720896 |
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| author | Florin Zamfirache Gabriela Prundaru Cristina Dumitru Beatrice Mihaela Radu |
| author_facet | Florin Zamfirache Gabriela Prundaru Cristina Dumitru Beatrice Mihaela Radu |
| contents | <p>3.2. Tracking Behavioural Decline Under Chronic Restraint <br>The study progressed with the implementation of the depression-inducing protocol using the <br>chronic movement restriction method (Figure 4). In this next analysis phase, we examined three key <br>time points: the beginning of the depression protocol, after completion, and the onset of sertraline <br>treatment. The analysis focused on alterations in the time spent by the animals exploring the central <br>area of the Open Field arena. A significant difference was observed between the “Start of the <br>Depression Protocol” and “Post-Depression Protocol” phases (p = 0.0245), indicating a reduction in <br>centre zone exploratory activity following the chronic stress period. This decline suggests a <br>progression in depression-like behaviour, consistent with reduced exploratory activity and increased <br>anxiety levels.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_15796015 |
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| publishDate | 2025 |
| publisher | Zenodo |
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| spellingShingle | Synergistic Effects of Pharmacological, Environmental, and Transcranial Direct Current Stimulation Interventions on Depression-Like Behaviours in Rats Under Social and Movement Restriction - Figure 4 Florin Zamfirache Gabriela Prundaru Cristina Dumitru Beatrice Mihaela Radu <p>3.2. Tracking Behavioural Decline Under Chronic Restraint <br>The study progressed with the implementation of the depression-inducing protocol using the <br>chronic movement restriction method (Figure 4). In this next analysis phase, we examined three key <br>time points: the beginning of the depression protocol, after completion, and the onset of sertraline <br>treatment. The analysis focused on alterations in the time spent by the animals exploring the central <br>area of the Open Field arena. A significant difference was observed between the “Start of the <br>Depression Protocol” and “Post-Depression Protocol” phases (p = 0.0245), indicating a reduction in <br>centre zone exploratory activity following the chronic stress period. This decline suggests a <br>progression in depression-like behaviour, consistent with reduced exploratory activity and increased <br>anxiety levels.</p> |
| title | Synergistic Effects of Pharmacological, Environmental, and Transcranial Direct Current Stimulation Interventions on Depression-Like Behaviours in Rats Under Social and Movement Restriction - Figure 4 |
| url | https://doi.org/10.5281/zenodo.15796015 |