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| Autori principali: | , , , , , , , , |
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| Natura: | Recurso digital |
| Lingua: | |
| Pubblicazione: |
Zenodo
2025
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| Soggetti: | |
| Accesso online: | https://doi.org/10.5281/zenodo.15825260 |
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Sommario:
- <p>Background: Gastrointestinal tract (GI) cancers are among the most common cancers affecting humans globally. The global incidence and mortality of the disease have demonstrated a significant temporal and geographic variation although the epidemiology and histopathologic characteristics have not been adequately reported among black Africans. In Nigeria, there is poor characterization of the disease due to lack of studies that reflect the epidemiology of the disease. Objective: This study aimed to examine the demographic and histopathological characteristics of gastrointestinal cancers in Northeastern Nigeria. Materials and Methods: This was a quantitative retrospective analysis of patients diagnosed with gastrointestinal cancers at six tertiary institutions in Northeastern Nigeria from January 2019 to December 2022. We selected six major tertiary referral centers to get diverse and representative data. Patient’s information retrieved included age, gender, organ(s) affected, tumor sub-sites, histological diagnosis, and histological sub-type of the tumor. The data collected was analyzed using SPSS version 26 (IBM SPSS Inc., Chicago, Illinois, USA). Results: A total of 579 patients were reviewed, within the age range 2 - 92 years, and a median age of 52 years. The incidence of GI cancers in this study was 16.1% (579/3596). There were 348 (60.1%) males and 231 (39.9%) females, with male-female ratio of 1.5:1. Majority of the patients 441 (76.2%) were 40 years or older. The common sites affected were the colorectal 279 (48.2%), liver 124 (21.4%), stomach 109 (18.8%), small intestine 32 (5.5%), esophagus 26 (4.5%), and pancreas 9 (1.6%). Overall, epithelial cancers (predominantly adenocarcinoma) were the commonest representing about 88.4% of the cases (512/579). All the pancreatic cancers were derived from the pancreatic ducts with 4 of them located at the head of the pancreas, while majority of the esophageal cancers were squamous cell carcinoma 15/26 (57.7%). Conclusion: The incidence of GI cancers in Northeastern Nigeria was 16.1%. The incidence is increasing with age, with a male preponderance. The most common site affected was the colorectal region, followed by the liver and stomach. The colorectal adenocarcinoma, gastric adenocarcinoma, and hepatocellular carcinoma are the most common histological subtypes.</p>