Egyptian perspective of research in sickle cell disease
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| Format: | Recurso digital |
| Sprache: | Englisch |
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2025
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| _version_ | 1866902067756400640 |
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| author | Elsayed Ebeid, Fatma Soliman |
| author_facet | Elsayed Ebeid, Fatma Soliman |
| contents | <p>Objective: Hemoglobinopathies including sickle cell disease (SCD) are prevalent inherited disorders in most Arab countries including Egypt. The heterogeneous distribution with variable prevalence in Egypt may be due to the historical trade exchange, high prevalence of consanguineous marriage, and internal migration.<br>Materials and methods: The literature search was conducted in the PubMed MEDLINE database including articles indexed as of 15th Apr 2024, if they involved patients with SCD in Egypt.<br>Results: In this work, we presented the research originated from Egypt addressing the SCD which includes case reports, original articles, and randomized clinical trials, and highlighted how this research efforts open the doors for understanding the prevalence and pathophysiology, improvement of the diagnostic methods, and the breakthrough treatment.<br>Conclusions: Although scanty research was carried out in the nineteenth century and the first decade of the twentieth century, SCD became an area of focus for research in 2010. The standard of care and the infrastructure improved with the involvement of several centres in multicenter international clinical trials.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_15831942 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Egyptian perspective of research in sickle cell disease Elsayed Ebeid, Fatma Soliman Sickle cell disease, Clinical research, Randomized controlled trial, SCD <p>Objective: Hemoglobinopathies including sickle cell disease (SCD) are prevalent inherited disorders in most Arab countries including Egypt. The heterogeneous distribution with variable prevalence in Egypt may be due to the historical trade exchange, high prevalence of consanguineous marriage, and internal migration.<br>Materials and methods: The literature search was conducted in the PubMed MEDLINE database including articles indexed as of 15th Apr 2024, if they involved patients with SCD in Egypt.<br>Results: In this work, we presented the research originated from Egypt addressing the SCD which includes case reports, original articles, and randomized clinical trials, and highlighted how this research efforts open the doors for understanding the prevalence and pathophysiology, improvement of the diagnostic methods, and the breakthrough treatment.<br>Conclusions: Although scanty research was carried out in the nineteenth century and the first decade of the twentieth century, SCD became an area of focus for research in 2010. The standard of care and the infrastructure improved with the involvement of several centres in multicenter international clinical trials.</p> |
| title | Egyptian perspective of research in sickle cell disease |
| topic | Sickle cell disease, Clinical research, Randomized controlled trial, SCD |
| url | https://doi.org/10.5281/zenodo.15831942 |