Prescription Pattern Analysis of Anti-Diabetic Drug and Anti-Hypertensive Drug with Associated Comorbidities
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| Format: | Recurso digital |
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2025
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| _version_ | 1866901679017820160 |
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| author | Sowmya Sri K*, Harrish Raj S, Bestiya Benedict, Kabilan J |
| author_facet | Sowmya Sri K*, Harrish Raj S, Bestiya Benedict, Kabilan J |
| contents | <p><span lang="EN">The present study evaluates the prescription patterns of anti-diabetic and anti-hypertensive drugs among inpatients with comorbid conditions in a tertiary care hospital. A prospective observational design was used, enrolling 70 diabetic and 80 hypertensive patients over a six-month period. Data were collected on demographic details, clinical characteristics, and prescribed medications, and analyzed in adherence to WHO prescribing indicators. Among hypertensive patients, calcium channel blockers (CCBs), particularly amlodipine, were the most prescribed monotherapy agents, followed by angiotensin receptor blockers (ARBs) and diuretics. Combination therapy, especially ARBs with CCBs, was frequently used to address coexisting conditions such as diabetes and chronic kidney disease. Most hypertensive patients were elderly and predominantly female. In diabetic patients, metformin emerged as the most commonly prescribed drug, both alone and in combinations with glimepiride, pioglitazone, and newer agents like vidagliptin and dapagliflozin, reflecting a blend of traditional and modern pharmacological approaches. Despite combination regimens, only 41% of patients achieved optimal glycemic control. Antibiotic co-prescription was observed in 34% of diabetic cases, with azithromycin and cephalosporins being the most common. WHO prescribing indicator analysis revealed rational drug use in terms of polypharmacy and injectable prescriptions; however, areas needing improvement include generic prescribing (85% vs. ideal 100%) and appropriate antibiotic utilization. This study underscores the need for continual prescription audits, adherence to evidence-based guidelines, and personalized treatment strategies to improve therapeutic outcomes in patients with diabetes, hypertension, and associated comorbidities.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_15974551 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Prescription Pattern Analysis of Anti-Diabetic Drug and Anti-Hypertensive Drug with Associated Comorbidities Sowmya Sri K*, Harrish Raj S, Bestiya Benedict, Kabilan J Diabetes, hypertension, prescription, drugs. <p><span lang="EN">The present study evaluates the prescription patterns of anti-diabetic and anti-hypertensive drugs among inpatients with comorbid conditions in a tertiary care hospital. A prospective observational design was used, enrolling 70 diabetic and 80 hypertensive patients over a six-month period. Data were collected on demographic details, clinical characteristics, and prescribed medications, and analyzed in adherence to WHO prescribing indicators. Among hypertensive patients, calcium channel blockers (CCBs), particularly amlodipine, were the most prescribed monotherapy agents, followed by angiotensin receptor blockers (ARBs) and diuretics. Combination therapy, especially ARBs with CCBs, was frequently used to address coexisting conditions such as diabetes and chronic kidney disease. Most hypertensive patients were elderly and predominantly female. In diabetic patients, metformin emerged as the most commonly prescribed drug, both alone and in combinations with glimepiride, pioglitazone, and newer agents like vidagliptin and dapagliflozin, reflecting a blend of traditional and modern pharmacological approaches. Despite combination regimens, only 41% of patients achieved optimal glycemic control. Antibiotic co-prescription was observed in 34% of diabetic cases, with azithromycin and cephalosporins being the most common. WHO prescribing indicator analysis revealed rational drug use in terms of polypharmacy and injectable prescriptions; however, areas needing improvement include generic prescribing (85% vs. ideal 100%) and appropriate antibiotic utilization. This study underscores the need for continual prescription audits, adherence to evidence-based guidelines, and personalized treatment strategies to improve therapeutic outcomes in patients with diabetes, hypertension, and associated comorbidities.</span></p> |
| title | Prescription Pattern Analysis of Anti-Diabetic Drug and Anti-Hypertensive Drug with Associated Comorbidities |
| topic | Diabetes, hypertension, prescription, drugs. |
| url | https://doi.org/10.5281/zenodo.15974551 |