Formulation Development and Analytical Method Development of Dapsone and Ethoxzolamide Bilayer Tablet Used in Treatment of Severe Burn Dissertation
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2025
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| _version_ | 1866901712506191872 |
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| author | Babu Anmulwad*, Asha Chopde, Dr. Pawan Avhad, Kiran Thorat, Pritam Ghadge |
| author_facet | Babu Anmulwad*, Asha Chopde, Dr. Pawan Avhad, Kiran Thorat, Pritam Ghadge |
| contents | <p><span lang="EN">The present study focuses on the formulation and analytical method development of bilayer tablets comprising Dapsone and Ethoxzolamide, intended for the effective treatment of severe burn conditions. Dapsone, an antibacterial agent, was formulated as an immediate release layer, while Ethoxzolamide, a diuretic and anti-inflammatory agent, was designed as a sustained release layer. The bilayer tablets were developed using direct compression technique, and various formulations were optimized based on excipient concentration and physical parameters. Pre-compression studies of powder blends revealed excellent flow properties. The prepared tablets were evaluated for weight variation, thickness, hardness, friability, drug content, and in vitro drug release. Analytical evaluations using UV spectroscopy, FTIR, and DSC confirmed drug identity and compatibility with excipients. The in vitro dissolution studies demonstrated desirable release profiles: Dapsone followed an immediate release pattern, and Ethoxzolamide showed a sustained release behavior. Drug release kinetics indicated that the matrix model best fit the release data. The study successfully developed a bilayer tablet system that ensures sequential drug delivery for enhanced therapeutic efficacy in burn treatment.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_16081643 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
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| spellingShingle | Formulation Development and Analytical Method Development of Dapsone and Ethoxzolamide Bilayer Tablet Used in Treatment of Severe Burn Dissertation Babu Anmulwad*, Asha Chopde, Dr. Pawan Avhad, Kiran Thorat, Pritam Ghadge Bilayer tablet, Dapsone, Ethoxzolamide, Severe burn, Immediate release, Sustained release, Direct compression, Drug release kinetics, Matrix model, UV spectroscopy, FTIR, DSC. <p><span lang="EN">The present study focuses on the formulation and analytical method development of bilayer tablets comprising Dapsone and Ethoxzolamide, intended for the effective treatment of severe burn conditions. Dapsone, an antibacterial agent, was formulated as an immediate release layer, while Ethoxzolamide, a diuretic and anti-inflammatory agent, was designed as a sustained release layer. The bilayer tablets were developed using direct compression technique, and various formulations were optimized based on excipient concentration and physical parameters. Pre-compression studies of powder blends revealed excellent flow properties. The prepared tablets were evaluated for weight variation, thickness, hardness, friability, drug content, and in vitro drug release. Analytical evaluations using UV spectroscopy, FTIR, and DSC confirmed drug identity and compatibility with excipients. The in vitro dissolution studies demonstrated desirable release profiles: Dapsone followed an immediate release pattern, and Ethoxzolamide showed a sustained release behavior. Drug release kinetics indicated that the matrix model best fit the release data. The study successfully developed a bilayer tablet system that ensures sequential drug delivery for enhanced therapeutic efficacy in burn treatment.</span></p> |
| title | Formulation Development and Analytical Method Development of Dapsone and Ethoxzolamide Bilayer Tablet Used in Treatment of Severe Burn Dissertation |
| topic | Bilayer tablet, Dapsone, Ethoxzolamide, Severe burn, Immediate release, Sustained release, Direct compression, Drug release kinetics, Matrix model, UV spectroscopy, FTIR, DSC. |
| url | https://doi.org/10.5281/zenodo.16081643 |