Correlation of TIMI Score and Killip Class with MACE In Non ST Elevation Myocardial Infarction
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2025
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| _version_ | 1866902048711114752 |
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| author | Dr Rondeep K N Sivam |
| author_facet | Dr Rondeep K N Sivam |
| contents | <div> <table> <tbody> <tr> <td style="padding: 0in 9.0pt 0in 9.0pt;"> <p><strong><span lang="EN-IN">OBJECTIVES: </span></strong><span lang="EN-IN">Non-ST-elevation myocardial infarction (NSTEMI) constitutes<span> </span>a significant proportion of acute coronary syndromes (ACS) and is a leading cause of morbidity and mortality worldwide. </span><span lang="EN-IN"><span> </span>TIMI score and Killip class are easily obtained clinical parameters to predict MACE . The objective </span><span lang="EN-IN">of this study is to assess the </span><span lang="EN-IN">correlation of TIMI score and Killip class<span> </span>with MACE<span> </span>in Non ST elevation myocardial<span> </span>infarction</span></p> <p><strong><span lang="EN-IN">METHODS : </span></strong><span lang="EN-IN">The study included 154 patients who presented to the Department of Cardiology, NEIGRIHMS, Shillong with NSTEMI . <span>Non-STEMI<span> </span>myocardial infarction is character­ized by abnormal cTnI ≥ 0.04 ng/ml.<span> </span>A 12-lead ECG was performed at admission in all cases and then at 6, 12, 18, 24 and 48 h post-admission.<span> </span>Blood samples were obtained after ≥ 6 hours since the beginning of the last episode of chest pain to assess cTnT .TIMI score and Killip class was calculated on admission . Major clinical events (MCE) observed up to 30 days post-dis­charge and considered as composite endpoint are: cardiac death, non-fatal myocardial and recurrent angina which led to ci­ne coronary angiography, and according to the results, the ensuing urgent revascularization treatment within 30 days of admis­sion. Patients were divided into two groups according to the presence (group A) or absence (group B) of MACE . </span>A ROC curve was generated to relate the TIMI score and Killip class<span> </span>with major cardiovascular events Sensitivity, specificity and positive predictive value was estimated for TIMI score and Killip classification<span> </span>for presence or absence of major cardiovascular events.</span></p> <p><strong><span lang="EN-IN">RESULTS: </span></strong><span lang="EN-IN">The mean TIMI score in patients with MACE<span> </span>was 3.76±0.75<span> </span>and<span> </span>was significantly higher<span> </span>in patients without MACE 2.24±0.84 (p≤0.001).</span></p> <p><span lang="EN-IN">In 33 of the 38 patients with MACE<span> </span>the TIMI SCORE was more than 2 while 51 of the 116 patients without MACE had TIMI SCORE>2. The number of<span> </span>patients with TIMI SCORE>2 had significantly higher rate of MACE . (p≤0.001). </span></p> <p><span lang="EN-IN">28 OF THE 38 patients with MACE had KILLIP CLASS > 1 ; while 15 of 116 patients without MACE had KILLIP CLASS > 1. The number of<span> </span>patients with KILLIP CLASS > 1had significantly higher rate of MACE . (p=0.004).</span></p> <p><strong><span lang="EN-IN">CONCLUSION: </span></strong><span lang="EN-IN">There is a significant<span> </span>correlation between TIMI score and Killip Class<span> </span>in prognosis of patients with Non ST elevation Myocardial Infarction<span> </span>. TIMI score and Killip class are easily available tools to predict<span> </span>MACE</span></p> </td> </tr> </tbody> </table> </div> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_16532460 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Correlation of TIMI Score and Killip Class with MACE In Non ST Elevation Myocardial Infarction Dr Rondeep K N Sivam <div> <table> <tbody> <tr> <td style="padding: 0in 9.0pt 0in 9.0pt;"> <p><strong><span lang="EN-IN">OBJECTIVES: </span></strong><span lang="EN-IN">Non-ST-elevation myocardial infarction (NSTEMI) constitutes<span> </span>a significant proportion of acute coronary syndromes (ACS) and is a leading cause of morbidity and mortality worldwide. </span><span lang="EN-IN"><span> </span>TIMI score and Killip class are easily obtained clinical parameters to predict MACE . The objective </span><span lang="EN-IN">of this study is to assess the </span><span lang="EN-IN">correlation of TIMI score and Killip class<span> </span>with MACE<span> </span>in Non ST elevation myocardial<span> </span>infarction</span></p> <p><strong><span lang="EN-IN">METHODS : </span></strong><span lang="EN-IN">The study included 154 patients who presented to the Department of Cardiology, NEIGRIHMS, Shillong with NSTEMI . <span>Non-STEMI<span> </span>myocardial infarction is character­ized by abnormal cTnI ≥ 0.04 ng/ml.<span> </span>A 12-lead ECG was performed at admission in all cases and then at 6, 12, 18, 24 and 48 h post-admission.<span> </span>Blood samples were obtained after ≥ 6 hours since the beginning of the last episode of chest pain to assess cTnT .TIMI score and Killip class was calculated on admission . Major clinical events (MCE) observed up to 30 days post-dis­charge and considered as composite endpoint are: cardiac death, non-fatal myocardial and recurrent angina which led to ci­ne coronary angiography, and according to the results, the ensuing urgent revascularization treatment within 30 days of admis­sion. Patients were divided into two groups according to the presence (group A) or absence (group B) of MACE . </span>A ROC curve was generated to relate the TIMI score and Killip class<span> </span>with major cardiovascular events Sensitivity, specificity and positive predictive value was estimated for TIMI score and Killip classification<span> </span>for presence or absence of major cardiovascular events.</span></p> <p><strong><span lang="EN-IN">RESULTS: </span></strong><span lang="EN-IN">The mean TIMI score in patients with MACE<span> </span>was 3.76±0.75<span> </span>and<span> </span>was significantly higher<span> </span>in patients without MACE 2.24±0.84 (p≤0.001).</span></p> <p><span lang="EN-IN">In 33 of the 38 patients with MACE<span> </span>the TIMI SCORE was more than 2 while 51 of the 116 patients without MACE had TIMI SCORE>2. The number of<span> </span>patients with TIMI SCORE>2 had significantly higher rate of MACE . (p≤0.001). </span></p> <p><span lang="EN-IN">28 OF THE 38 patients with MACE had KILLIP CLASS > 1 ; while 15 of 116 patients without MACE had KILLIP CLASS > 1. The number of<span> </span>patients with KILLIP CLASS > 1had significantly higher rate of MACE . (p=0.004).</span></p> <p><strong><span lang="EN-IN">CONCLUSION: </span></strong><span lang="EN-IN">There is a significant<span> </span>correlation between TIMI score and Killip Class<span> </span>in prognosis of patients with Non ST elevation Myocardial Infarction<span> </span>. TIMI score and Killip class are easily available tools to predict<span> </span>MACE</span></p> </td> </tr> </tbody> </table> </div> |
| title | Correlation of TIMI Score and Killip Class with MACE In Non ST Elevation Myocardial Infarction |
| url | https://doi.org/10.5281/zenodo.16532460 |