A Comparative Study of Mucin Expression in Colorectal Adenocarcinoma and Normal Colonic Mucosa
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| Format: | Recurso digital |
| Langue: | anglais |
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2025
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| author | International Journal of Medical Science and Advanced Clinical Research (IJMACR) |
| author_facet | International Journal of Medical Science and Advanced Clinical Research (IJMACR) |
| contents | <p><strong><span lang="EN-US">Abstract</span></strong></p> <p><strong><span>Background: </span></strong><span>Colorectal cancer poses a significant global health concern<strong>. </strong>The majority of colorectal carcinomas are adenocarcinomas. Deregulation of mucin expression has been reported in various gastrointestinal lesions progressing to cancer. Mucin expression by the tumour cells influences the prognosis and therapeutic management. </span></p> <p><strong><span>Aim: </span></strong><span>To determine the type of mucin in normal mucosa and adenocarcinoma of the colorectal region. </span></p> <p><strong><span>Material and Methods: </span></strong><span>A total of 15 consecutive cases of colorectal carcinoma and 15 controls of normal colonic mucosa were included in each group. The samples were received in 10% neutral buffered formalin, processed, embedded in paraffin and serial sections of 4-5 microns were prepared. The tissue was stained by H & E and special stains such as PAS, Alcian blue (pH -2.5), and combined AB – PAS. The percentage of mucin-positive cells was noted. </span></p> <p><strong><span>Results: </span></strong><span>In our study, there was a predominance of acidic mucins with traces of neutral mucins in cases (group 1) and a predominance of acidic mucins along with some amount of neutral mucins in controls (group 2). Compared to cases (group 1) the amount of neutral mucins was more in controls (group 2). </span></p> <p><strong><span>Conclusion: </span></strong><span>The percentage of cells showing acidic mucins on AB-PAS stain was significantly higher in colorectal adenocarcinoma cases as compared to normal colonic mucosa. The results of the present study including mucin content and type may be helpful in understanding the pathogenesis of colorectal carcinoma</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_16737056 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | A Comparative Study of Mucin Expression in Colorectal Adenocarcinoma and Normal Colonic Mucosa International Journal of Medical Science and Advanced Clinical Research (IJMACR) Keywords: Colorectal adenocarcinoma, Mucins <p><strong><span lang="EN-US">Abstract</span></strong></p> <p><strong><span>Background: </span></strong><span>Colorectal cancer poses a significant global health concern<strong>. </strong>The majority of colorectal carcinomas are adenocarcinomas. Deregulation of mucin expression has been reported in various gastrointestinal lesions progressing to cancer. Mucin expression by the tumour cells influences the prognosis and therapeutic management. </span></p> <p><strong><span>Aim: </span></strong><span>To determine the type of mucin in normal mucosa and adenocarcinoma of the colorectal region. </span></p> <p><strong><span>Material and Methods: </span></strong><span>A total of 15 consecutive cases of colorectal carcinoma and 15 controls of normal colonic mucosa were included in each group. The samples were received in 10% neutral buffered formalin, processed, embedded in paraffin and serial sections of 4-5 microns were prepared. The tissue was stained by H & E and special stains such as PAS, Alcian blue (pH -2.5), and combined AB – PAS. The percentage of mucin-positive cells was noted. </span></p> <p><strong><span>Results: </span></strong><span>In our study, there was a predominance of acidic mucins with traces of neutral mucins in cases (group 1) and a predominance of acidic mucins along with some amount of neutral mucins in controls (group 2). Compared to cases (group 1) the amount of neutral mucins was more in controls (group 2). </span></p> <p><strong><span>Conclusion: </span></strong><span>The percentage of cells showing acidic mucins on AB-PAS stain was significantly higher in colorectal adenocarcinoma cases as compared to normal colonic mucosa. The results of the present study including mucin content and type may be helpful in understanding the pathogenesis of colorectal carcinoma</span></p> |
| title | A Comparative Study of Mucin Expression in Colorectal Adenocarcinoma and Normal Colonic Mucosa |
| topic | Keywords: Colorectal adenocarcinoma, Mucins |
| url | https://doi.org/10.5281/zenodo.16737056 |