EFFECT OF CAPSICUM ANNUUM ON THE LIVER FUNCTION OF ASPIRIN-INDUCED WISTAR ALBINO RATS
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2025
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| author | Edoga, Cyril Onyekachi Ezema, Christiana Onyinyechi Sowunmi, Kehinde Olukemi |
| author_facet | Edoga, Cyril Onyekachi Ezema, Christiana Onyinyechi Sowunmi, Kehinde Olukemi |
| contents | <p>Peptic ulcer disease remains one of the most prevalent gastrointestinal diseases and has been linked to H. pylori infection and the use of non-steroidal anti-inflammatory drugs. Capsicum annum is known for its anti-inflammatory, antioxidant, antibacterial, nutritional, and medicinal properties. This study aimed to determine the effects of aspirin on liver function parameters (alanine aminotransferase, alkaline phosphate, serum aspartate aminotransferase, and gamma-glutamyl transferase) in male Wistar albino rats. Twenty-five (25) male wistar albino rats were procured and acclimatized for 2 weeks under normal laboratory conditions and were divided into five groups. Group A (blank control) was fed only food and water and was neither induced with aspirin nor treated. Group B (negative control) was induced with 50 mg/kg of aspirin and was not treated. Group C (positive control) was induced with 50 mg/kg of aspirin and was treated with omeprazole. Group D (low-dose Capsicum anuum) was induced with aspirin and treated with 100 mg/kg of C. annum extract, and group E (high-dose control) was induced with aspirin and treated with 400 mg/kg of Capsicum annum ethanoic extract. Ulceration and treatment were administered orally via intubation. After 4 weeks of treatment, ulceration significantly increased the alanine aminotransferase level (p > 0.05) in the negative control group (28.06 ± 2.10) and decreased when treated with both low-dose and high-dose Capsicum annum extract (25.20 ± 2.40, 21.70 ± 1.80). Changes in other parameters were significant in the low- and high-dose treatments, indicating that the changes in these parameters are dose-dependent.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_16901555 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | EFFECT OF CAPSICUM ANNUUM ON THE LIVER FUNCTION OF ASPIRIN-INDUCED WISTAR ALBINO RATS Edoga, Cyril Onyekachi Ezema, Christiana Onyinyechi Sowunmi, Kehinde Olukemi Capsicum annum, Omeprazole, Ulcer, Aspirin <p>Peptic ulcer disease remains one of the most prevalent gastrointestinal diseases and has been linked to H. pylori infection and the use of non-steroidal anti-inflammatory drugs. Capsicum annum is known for its anti-inflammatory, antioxidant, antibacterial, nutritional, and medicinal properties. This study aimed to determine the effects of aspirin on liver function parameters (alanine aminotransferase, alkaline phosphate, serum aspartate aminotransferase, and gamma-glutamyl transferase) in male Wistar albino rats. Twenty-five (25) male wistar albino rats were procured and acclimatized for 2 weeks under normal laboratory conditions and were divided into five groups. Group A (blank control) was fed only food and water and was neither induced with aspirin nor treated. Group B (negative control) was induced with 50 mg/kg of aspirin and was not treated. Group C (positive control) was induced with 50 mg/kg of aspirin and was treated with omeprazole. Group D (low-dose Capsicum anuum) was induced with aspirin and treated with 100 mg/kg of C. annum extract, and group E (high-dose control) was induced with aspirin and treated with 400 mg/kg of Capsicum annum ethanoic extract. Ulceration and treatment were administered orally via intubation. After 4 weeks of treatment, ulceration significantly increased the alanine aminotransferase level (p > 0.05) in the negative control group (28.06 ± 2.10) and decreased when treated with both low-dose and high-dose Capsicum annum extract (25.20 ± 2.40, 21.70 ± 1.80). Changes in other parameters were significant in the low- and high-dose treatments, indicating that the changes in these parameters are dose-dependent.</p> |
| title | EFFECT OF CAPSICUM ANNUUM ON THE LIVER FUNCTION OF ASPIRIN-INDUCED WISTAR ALBINO RATS |
| topic | Capsicum annum, Omeprazole, Ulcer, Aspirin |
| url | https://doi.org/10.5281/zenodo.16901555 |