The Gut-Brain Axis in Alzheimer's Disease:Mechanisms,Microbiota and Potential Therapeutic Strategies
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| Natura: | Recurso digital |
| Lingua: | inglese |
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2025
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| _version_ | 1866902232120688640 |
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| author | Robert Gdula Kinga Cogiel Julia Sokal Karol Płaszewski Jan Polaczek-Kornecki Michał Godek Norbert Jamrozik Szymon Jan Szostek Jakub Sokołowski |
| author_facet | Robert Gdula Kinga Cogiel Julia Sokal Karol Płaszewski Jan Polaczek-Kornecki Michał Godek Norbert Jamrozik Szymon Jan Szostek Jakub Sokołowski |
| contents | <p><span><span lang="PL">ABSTRACT</span></span></p> <p><strong><span><span lang="PL">Introduction:</span></span></strong><span><span lang="PL"><br>Alzheimer’s disease (AD) is the most common form of dementia and represents a major challenge</span></span></p> <p><span><span lang="PL">in modern medicine due to its<span> </span>global prevalence. In recent years, growing interest in the gut microbiota has revealed potential links between microbial dysbiosis and the development and progression of AD. These findings suggest novel perspectives in AD pathogenesis and therapeutic approaches.</span></span></p> <p><strong><span><span lang="PL">Purpose:</span></span></strong><span lang="PL"><br>This review aims to investigate the current evidence supporting the connection between gut microbiota and Alzheimer’s disease, focusing on the gut-brain axis mechanisms and evaluating microbiome-targeted therapeutic strategies.</span></p> <p><strong><span><span lang="PL">Methods:</span></span></strong><span lang="PL"><br>A comprehensive literature review was conducted using peer-reviewed articles sourced from PubMed and other scientific databases. The search focused on studies exploring the gut-brain axis, neuroinflammation, microbiota composition in AD , and microbiome-based interventions<span> </span>from 2012 to 2025. Both animal and human studies were included.</span></p> <p><strong><span><span lang="PL">Results:</span></span></strong><span lang="PL"><br>Current research indicates that gut microbiota dysbiosis may contribute to Alzheimer’s disease via direct microbial invasion and indirect neuroimmune mechanisms, such as systemic inflammation and blood-brain barrier disruption. AD patients often exhibit increased pro-inflammatory and decreased anti-inflammatory gut bacteria, correlating with neuroinflammation and accumulation of β-amyloid and tau. Emerging therapies like probiotics, fecal microbiota transplantation, and lifestyle changes show promise in modulating the microbiome and alleviating AD-related pathology. </span></p> <p><strong><span><span lang="PL">Conclusions:</span></span></strong><span lang="PL"><br>Gut microbiota dysbiosis appears to influence Alzheimer’s disease progression via neuroinflammatory and neurodegenerative pathways. Targeting the gut-brain axis may offer promising therapeutic avenues. However, further research is necessary to clarify causality, optimize interventions, and validate findings in large-scale human trials.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_16932272 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | The Gut-Brain Axis in Alzheimer's Disease:Mechanisms,Microbiota and Potential Therapeutic Strategies Robert Gdula Kinga Cogiel Julia Sokal Karol Płaszewski Jan Polaczek-Kornecki Michał Godek Norbert Jamrozik Szymon Jan Szostek Jakub Sokołowski Alzheimer's disease, gut-brain axis, gut microbiota, neuroinflammation, microbiome-based therapy <p><span><span lang="PL">ABSTRACT</span></span></p> <p><strong><span><span lang="PL">Introduction:</span></span></strong><span><span lang="PL"><br>Alzheimer’s disease (AD) is the most common form of dementia and represents a major challenge</span></span></p> <p><span><span lang="PL">in modern medicine due to its<span> </span>global prevalence. In recent years, growing interest in the gut microbiota has revealed potential links between microbial dysbiosis and the development and progression of AD. These findings suggest novel perspectives in AD pathogenesis and therapeutic approaches.</span></span></p> <p><strong><span><span lang="PL">Purpose:</span></span></strong><span lang="PL"><br>This review aims to investigate the current evidence supporting the connection between gut microbiota and Alzheimer’s disease, focusing on the gut-brain axis mechanisms and evaluating microbiome-targeted therapeutic strategies.</span></p> <p><strong><span><span lang="PL">Methods:</span></span></strong><span lang="PL"><br>A comprehensive literature review was conducted using peer-reviewed articles sourced from PubMed and other scientific databases. The search focused on studies exploring the gut-brain axis, neuroinflammation, microbiota composition in AD , and microbiome-based interventions<span> </span>from 2012 to 2025. Both animal and human studies were included.</span></p> <p><strong><span><span lang="PL">Results:</span></span></strong><span lang="PL"><br>Current research indicates that gut microbiota dysbiosis may contribute to Alzheimer’s disease via direct microbial invasion and indirect neuroimmune mechanisms, such as systemic inflammation and blood-brain barrier disruption. AD patients often exhibit increased pro-inflammatory and decreased anti-inflammatory gut bacteria, correlating with neuroinflammation and accumulation of β-amyloid and tau. Emerging therapies like probiotics, fecal microbiota transplantation, and lifestyle changes show promise in modulating the microbiome and alleviating AD-related pathology. </span></p> <p><strong><span><span lang="PL">Conclusions:</span></span></strong><span lang="PL"><br>Gut microbiota dysbiosis appears to influence Alzheimer’s disease progression via neuroinflammatory and neurodegenerative pathways. Targeting the gut-brain axis may offer promising therapeutic avenues. However, further research is necessary to clarify causality, optimize interventions, and validate findings in large-scale human trials.</span></p> |
| title | The Gut-Brain Axis in Alzheimer's Disease:Mechanisms,Microbiota and Potential Therapeutic Strategies |
| topic | Alzheimer's disease, gut-brain axis, gut microbiota, neuroinflammation, microbiome-based therapy |
| url | https://doi.org/10.5281/zenodo.16932272 |