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| Format: | Recurso digital |
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Zenodo
2025
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| Online Access: | https://doi.org/10.5281/zenodo.16933448 |
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Table of Contents:
- <p>The principle behind writing this review on the floating drug delivery system (FDDS) had as its<br>main goal organizing the latest research on the fundamental role that flotation plays in gaining gastric<br>retention. The buoyancy mechanism serves as the foundation for the various techniques utilized in the<br>development of FDDS, including the construction of both effervescent and non-effervescent floating<br>tablets. Drugs that are unstable in the lower intestine environment, have a limited window of absorption in<br>the upper gastrointestinal system, and are poorly soluble at higher pH levels can be delivered via the<br>FDDS technique. Among the innovative techniques in FDDS are methods for designing floating systems<br>with one or more units. The design of single- and multi-unit floating systems, the physiological and<br>formulation variability influencing stomach retention, and the application of recently created and produced<br>polymers are some of the novel methodology in FDDS. In light of the functionality and applications of<br>floating systems, this review also emphasizes a variety of in vitro methods and in vivo investigations. In<br>addition to the gas-generating agent, appropriate components can be added to tablets or capsules to create<br>floating dosage forms that can be administered conventionally. </p>