The Computational Organellopathy: Failure Modes of Cellular Vaults as a Foundational Principle in Chronic and Developmental Pathologies
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2025
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| _version_ | 1866902329631965184 |
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| author | Mitchell, D. B. |
| author_facet | Mitchell, D. B. |
| contents | <p>Metabolic syndrome, cancer, major depression, Parkinson's disease, autism, and osteoporosis are understood as disparate pathologies, for which a unified mechanistic theory has seemed impossible. Here, we advance just such a framework, positing that these conditions represent distinct failure modes of a single, fundamental biological machine: the cellular vault complex. Building on a first-principles model of the vault as a subcellular cognitive system, we introduce a new disease paradigm: the Computational Organellopathy. To validate this paradigm, we synthesize multi-scale evidence from six seemingly disparate case studies, arguing that: (1) Metabolic Syndrome arises from system overload. (2) Cancer executes hardware amplification via quality-control sabotage. (3) Major Depression is linked to hardware fragility. (4) Parkinson's Disease arises from software misregulation. (5) Autism Spectrum Disorder stems from developmental hardware failure. (6) Osteoporosis is driven by age-related hardware degradation. This framework reframes a vast class of human suffering as pathologies of subcellular information processing and reveals an inevitable therapeutic horizon: a new class of Informational Medicine designed not to destroy cellular hardware, but to reprogram the computational logic that governs cellular health.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_16943474 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
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| spellingShingle | The Computational Organellopathy: Failure Modes of Cellular Vaults as a Foundational Principle in Chronic and Developmental Pathologies Mitchell, D. B. Cellular Vault Vault RNA (vRNA) Major Vault Protein (MVP) Computational Organellopathy Free Energy Principle (FEP) Informational Medicine Inflammation Metabolic Syndrome Cancer Oncology Depression Psychiatry Parkinson Disease Neurodegenerative Diseases Autism Spectrum Disorder Osteoporosis RNA Biology Systems Biology Computational Biology Molecular Biology Cell Biology Biophysics Theoretical Biology Quantum Biology <p>Metabolic syndrome, cancer, major depression, Parkinson's disease, autism, and osteoporosis are understood as disparate pathologies, for which a unified mechanistic theory has seemed impossible. Here, we advance just such a framework, positing that these conditions represent distinct failure modes of a single, fundamental biological machine: the cellular vault complex. Building on a first-principles model of the vault as a subcellular cognitive system, we introduce a new disease paradigm: the Computational Organellopathy. To validate this paradigm, we synthesize multi-scale evidence from six seemingly disparate case studies, arguing that: (1) Metabolic Syndrome arises from system overload. (2) Cancer executes hardware amplification via quality-control sabotage. (3) Major Depression is linked to hardware fragility. (4) Parkinson's Disease arises from software misregulation. (5) Autism Spectrum Disorder stems from developmental hardware failure. (6) Osteoporosis is driven by age-related hardware degradation. This framework reframes a vast class of human suffering as pathologies of subcellular information processing and reveals an inevitable therapeutic horizon: a new class of Informational Medicine designed not to destroy cellular hardware, but to reprogram the computational logic that governs cellular health.</p> |
| title | The Computational Organellopathy: Failure Modes of Cellular Vaults as a Foundational Principle in Chronic and Developmental Pathologies |
| topic | Cellular Vault Vault RNA (vRNA) Major Vault Protein (MVP) Computational Organellopathy Free Energy Principle (FEP) Informational Medicine Inflammation Metabolic Syndrome Cancer Oncology Depression Psychiatry Parkinson Disease Neurodegenerative Diseases Autism Spectrum Disorder Osteoporosis RNA Biology Systems Biology Computational Biology Molecular Biology Cell Biology Biophysics Theoretical Biology Quantum Biology |
| url | https://doi.org/10.5281/zenodo.16943474 |