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| Format: | Recurso digital |
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Zenodo
2025
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| Online Access: | https://doi.org/10.5281/zenodo.16943474 |
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Table of Contents:
- <p>Metabolic syndrome, cancer, major depression, Parkinson's disease, autism, and osteoporosis are understood as disparate pathologies, for which a unified mechanistic theory has seemed impossible. Here, we advance just such a framework, positing that these conditions represent distinct failure modes of a single, fundamental biological machine: the cellular vault complex. Building on a first-principles model of the vault as a subcellular cognitive system, we introduce a new disease paradigm: the Computational Organellopathy. To validate this paradigm, we synthesize multi-scale evidence from six seemingly disparate case studies, arguing that: (1) Metabolic Syndrome arises from system overload. (2) Cancer executes hardware amplification via quality-control sabotage. (3) Major Depression is linked to hardware fragility. (4) Parkinson's Disease arises from software misregulation. (5) Autism Spectrum Disorder stems from developmental hardware failure. (6) Osteoporosis is driven by age-related hardware degradation. This framework reframes a vast class of human suffering as pathologies of subcellular information processing and reveals an inevitable therapeutic horizon: a new class of Informational Medicine designed not to destroy cellular hardware, but to reprogram the computational logic that governs cellular health.</p>