Effect of Extreme Photoperiodic Condition-constant Dark and Melatonin Pretreatment on Ampicillin induced Nephrotoxicity in Wild Tropical Rodent, Indian palm squirrel, F. pennanti.
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2020
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| _version_ | 1866902170529431552 |
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| author | CHANDRA, Dr DINESH |
| author_facet | CHANDRA, Dr DINESH |
| contents | <p>Introduction:<br>From the previous studies, it is quite evident that Ampicillin sodium at a lower dose<br>(40mg/Kg body wt) in wild tropical rodent Funambulus pennanti produces nephrotoxicity by<br>increasing free radical load. This toxicity is limited by pretreatment of melatonin with<br>physiological dose (250μg/kg body wt) in Rattus norvagicus and at higher doses (500μg/kg<br>body wt) in Funambulus pennanti. Recent work indicated that constant light suppressed<br>hydroxyindole-O-methyltransferase (HIOMT) activity and constant dark increased it (Arendt,<br>1995) when HIOMT does not show a definite rhythm in 24 hour light/dark cycle. Further,<br>circadian rhythms in general which are well defined in light-dark cycles persist or free run<br>under CD conditions and are suppressed by constant light (Binkley, 1993). In the night at about<br>2am to 3am is the point when melatonin reaches its peak, and probably due to the increased<br>concentration of melatonin, lipid peroxidation is reduced. Thus, melatonin decreases lipid<br>peroxidation directly and indirectly by stimulating GSH-Px activity. Belanger et al. (1991)<br>reported that the minimal lipid peroxidation level in rat liver tissue was at 01:00 h which the<br>appropriate peak time of melatonin. It may be the increase in melatonin secretion during night<br>responsible for, at least in part, for the nocturnal elevation of total antioxidative status and for<br>the reduction of lipid peroxidation observed in Indian palm squirrel.<br>Considering these data in relation to melatonin and antioxidant systems in kidney,<br>(Pierrefiche and Laborit, 1995) under-took the present research. The main aim was to evaluate<br>the exogenous effects of melatonin and constant dark exposure on antioxidant enzyme activities<br>in renal tissue (TAS% and SOD), oxidative stress lipid peroxidation level (TBARS) with<br>biochemical parameters like acid phosphatase (ACP), alkaline phosphatese (ALP), creatinine<br>and urea in both blood (BUN) and urine to access the functional status of kidney and as a<br>whole the organism.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17025416 |
| institution | Zenodo |
| language | eng |
| publishDate | 2020 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Effect of Extreme Photoperiodic Condition-constant Dark and Melatonin Pretreatment on Ampicillin induced Nephrotoxicity in Wild Tropical Rodent, Indian palm squirrel, F. pennanti. CHANDRA, Dr DINESH Melatonin Antioxidants Neurotoxicity nephrotoxicity <p>Introduction:<br>From the previous studies, it is quite evident that Ampicillin sodium at a lower dose<br>(40mg/Kg body wt) in wild tropical rodent Funambulus pennanti produces nephrotoxicity by<br>increasing free radical load. This toxicity is limited by pretreatment of melatonin with<br>physiological dose (250μg/kg body wt) in Rattus norvagicus and at higher doses (500μg/kg<br>body wt) in Funambulus pennanti. Recent work indicated that constant light suppressed<br>hydroxyindole-O-methyltransferase (HIOMT) activity and constant dark increased it (Arendt,<br>1995) when HIOMT does not show a definite rhythm in 24 hour light/dark cycle. Further,<br>circadian rhythms in general which are well defined in light-dark cycles persist or free run<br>under CD conditions and are suppressed by constant light (Binkley, 1993). In the night at about<br>2am to 3am is the point when melatonin reaches its peak, and probably due to the increased<br>concentration of melatonin, lipid peroxidation is reduced. Thus, melatonin decreases lipid<br>peroxidation directly and indirectly by stimulating GSH-Px activity. Belanger et al. (1991)<br>reported that the minimal lipid peroxidation level in rat liver tissue was at 01:00 h which the<br>appropriate peak time of melatonin. It may be the increase in melatonin secretion during night<br>responsible for, at least in part, for the nocturnal elevation of total antioxidative status and for<br>the reduction of lipid peroxidation observed in Indian palm squirrel.<br>Considering these data in relation to melatonin and antioxidant systems in kidney,<br>(Pierrefiche and Laborit, 1995) under-took the present research. The main aim was to evaluate<br>the exogenous effects of melatonin and constant dark exposure on antioxidant enzyme activities<br>in renal tissue (TAS% and SOD), oxidative stress lipid peroxidation level (TBARS) with<br>biochemical parameters like acid phosphatase (ACP), alkaline phosphatese (ALP), creatinine<br>and urea in both blood (BUN) and urine to access the functional status of kidney and as a<br>whole the organism.</p> |
| title | Effect of Extreme Photoperiodic Condition-constant Dark and Melatonin Pretreatment on Ampicillin induced Nephrotoxicity in Wild Tropical Rodent, Indian palm squirrel, F. pennanti. |
| topic | Melatonin Antioxidants Neurotoxicity nephrotoxicity |
| url | https://doi.org/10.5281/zenodo.17025416 |