Toxicological Evaluation of Hepatic, Renal and Oxidative Stress Parameters in Xylene Treated Wistar Rats
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2025
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| author | Olubunmi, Ezomoh Olusoga Anakwe, Chukwuma Samuel Collins, Ogu Oyinbrakemi Peter, Ogbara Kievelezebo Prophet, Prohp The |
| author_facet | Olubunmi, Ezomoh Olusoga Anakwe, Chukwuma Samuel Collins, Ogu Oyinbrakemi Peter, Ogbara Kievelezebo Prophet, Prohp The |
| contents | <p>This study investigated the dose-dependent toxicological effects of subacute xylene exposure on <br>hepatic, renal, and oxidative stress parameters in Wistar rats. Forty adult male rats were divided <br>into ten groups (n=6). The normal control group (Group 1) received distilled water, while Groups <br>2 to 10 were administered increasing doses of xylene (0.125 to (7 mL/kg) body weight) via oral <br>gavage for 28 days. Significant mortality was observed, with all animals in groups receiving ≥ (3 <br>mL/kg) succumbing before the study concluded, limiting biochemical analysis to Groups 1-5 (0- <br>(1 mL/kg)). Xylene exposure induced severe, dose-dependent hepatotoxicity, evidenced by <br>significant elevation in serum ALT, AST, ALP, and total bilirubin, alongside decreased total <br>protein and albumin. Nephrotoxicity was indicated by increased urea and creatinine levels and a <br>significant disruption in electrolyte and acid-base homeostasis. Mechanistically, a significant <br>depletion of antioxidant enzymes (SOD, CAT, GPx) and a rise in lipid peroxidation (MDA) were <br>observed in both liver and kidney tissues, implicating oxidative stress as a central pathway of <br>toxicity. The results provide evidence that xylene induces multi-organ toxicity primarily through <br>an oxidative mechanism, culminating in organ failure and mortality at higher doses. These findings <br>highlight a substantial occupational health risk and underscore the need for stringent exposure <br>control measures. </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17093731 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
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| spellingShingle | Toxicological Evaluation of Hepatic, Renal and Oxidative Stress Parameters in Xylene Treated Wistar Rats Olubunmi, Ezomoh Olusoga Anakwe, Chukwuma Samuel Collins, Ogu Oyinbrakemi Peter, Ogbara Kievelezebo Prophet, Prohp The Antioxidants Hepatotoxicity Lipid peroxidation Renal toxicity Xylene <p>This study investigated the dose-dependent toxicological effects of subacute xylene exposure on <br>hepatic, renal, and oxidative stress parameters in Wistar rats. Forty adult male rats were divided <br>into ten groups (n=6). The normal control group (Group 1) received distilled water, while Groups <br>2 to 10 were administered increasing doses of xylene (0.125 to (7 mL/kg) body weight) via oral <br>gavage for 28 days. Significant mortality was observed, with all animals in groups receiving ≥ (3 <br>mL/kg) succumbing before the study concluded, limiting biochemical analysis to Groups 1-5 (0- <br>(1 mL/kg)). Xylene exposure induced severe, dose-dependent hepatotoxicity, evidenced by <br>significant elevation in serum ALT, AST, ALP, and total bilirubin, alongside decreased total <br>protein and albumin. Nephrotoxicity was indicated by increased urea and creatinine levels and a <br>significant disruption in electrolyte and acid-base homeostasis. Mechanistically, a significant <br>depletion of antioxidant enzymes (SOD, CAT, GPx) and a rise in lipid peroxidation (MDA) were <br>observed in both liver and kidney tissues, implicating oxidative stress as a central pathway of <br>toxicity. The results provide evidence that xylene induces multi-organ toxicity primarily through <br>an oxidative mechanism, culminating in organ failure and mortality at higher doses. These findings <br>highlight a substantial occupational health risk and underscore the need for stringent exposure <br>control measures. </p> |
| title | Toxicological Evaluation of Hepatic, Renal and Oxidative Stress Parameters in Xylene Treated Wistar Rats |
| topic | Antioxidants Hepatotoxicity Lipid peroxidation Renal toxicity Xylene |
| url | https://doi.org/10.5281/zenodo.17093731 |