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2025
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| Online Access: | https://doi.org/10.5281/zenodo.17117313 |
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| author | Omar Ahmed Hassoon Ammar, Dhouha Ghribi Aydi |
| author_facet | Omar Ahmed Hassoon Ammar, Dhouha Ghribi Aydi |
| contents | <p><span lang="EN-US">There is an increasing interest in the beneficial effects of green tea extracts, which are effective against various diseases due to the bioactive compounds they contain. Researchers have investigated the ability of green tea extract to inhibit microbial growth due to its polyphenolic compounds, particularly catechins. This study examines the antimicrobial effect of <em>Camellia sinensis</em> extract on clinical bacterial isolates obtained from wound and burn infections, as well as its impact on the gene expression of efflux pump regulator (EMR), penicillin-binding protein (PBP), metal-β-lactamase (MPH), and AmpC β-lactamase (AMP). Samples were collected from clinical cases of wounds and burns; the bacterial isolates were cultured and characterized using conventional methods. The minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of <em>C. sinensis</em> extract against the isolates were also determined. The bioactive composition of <em>C. sinensis</em> extract was analyzed, and real-time PCR was used to assess gene expression, with relative quantification of EMR, PBP, MPH, and AMP genes in the presence and absence of <em>C. sinensis</em> extract.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17117313 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Benefits of Wild Plant: Camellia sinensis extract usage in medicine Omar Ahmed Hassoon Ammar, Dhouha Ghribi Aydi <p><span lang="EN-US">There is an increasing interest in the beneficial effects of green tea extracts, which are effective against various diseases due to the bioactive compounds they contain. Researchers have investigated the ability of green tea extract to inhibit microbial growth due to its polyphenolic compounds, particularly catechins. This study examines the antimicrobial effect of <em>Camellia sinensis</em> extract on clinical bacterial isolates obtained from wound and burn infections, as well as its impact on the gene expression of efflux pump regulator (EMR), penicillin-binding protein (PBP), metal-β-lactamase (MPH), and AmpC β-lactamase (AMP). Samples were collected from clinical cases of wounds and burns; the bacterial isolates were cultured and characterized using conventional methods. The minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of <em>C. sinensis</em> extract against the isolates were also determined. The bioactive composition of <em>C. sinensis</em> extract was analyzed, and real-time PCR was used to assess gene expression, with relative quantification of EMR, PBP, MPH, and AMP genes in the presence and absence of <em>C. sinensis</em> extract.</span></p> |
| title | Benefits of Wild Plant: Camellia sinensis extract usage in medicine |
| url | https://doi.org/10.5281/zenodo.17117313 |