Saved in:
| Main Author: | |
|---|---|
| Format: | Recurso digital |
| Language: | |
| Published: |
Zenodo
2025
|
| Online Access: | https://doi.org/10.5281/zenodo.17195367 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866902102787227648 |
|---|---|
| author | Mamoor, Shahan |
| author_facet | Mamoor, Shahan |
| contents | <p dir="ltr">Metastasis is the major cause of death from cancer and metastasis to the lung in breast cancer is difficult to treat and heterogeneous in nature, complicating its management (1-5). We recently utilized whole transcriptome technologies to define the full complement of differentially expressed kinases and phosphatases in HER2+ breast cancer: in the primary tumor, and in metastasis to the CNS (6-8). Here we utilize whole transcriptome technologies (9, 10) to measure total transcription in the lung metastases of humans with breast cancer, integrating this with transcriptome data from a cell culture model of lung metastatic potential. We identify here a therapeutic target based on its differential expression and up-regulation upon metastasis to the lung in humans with breast cancer, GRIK4, as a candidate therapeutic target for the medical management of lung metastasis. </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17195367 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Immunoglobulin-based therapeutic targeting in breast cancer for the treatment of lung metastasis: GRIK4. Mamoor, Shahan <p dir="ltr">Metastasis is the major cause of death from cancer and metastasis to the lung in breast cancer is difficult to treat and heterogeneous in nature, complicating its management (1-5). We recently utilized whole transcriptome technologies to define the full complement of differentially expressed kinases and phosphatases in HER2+ breast cancer: in the primary tumor, and in metastasis to the CNS (6-8). Here we utilize whole transcriptome technologies (9, 10) to measure total transcription in the lung metastases of humans with breast cancer, integrating this with transcriptome data from a cell culture model of lung metastatic potential. We identify here a therapeutic target based on its differential expression and up-regulation upon metastasis to the lung in humans with breast cancer, GRIK4, as a candidate therapeutic target for the medical management of lung metastasis. </p> |
| title | Immunoglobulin-based therapeutic targeting in breast cancer for the treatment of lung metastasis: GRIK4. |
| url | https://doi.org/10.5281/zenodo.17195367 |