INSULIN RESISTANCE AS A PREDICTOR OF PROGNOSIS IN NONDIABETIC PATIENTS WITH ACUTE ISCHEMIC STROKE
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2025
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| _version_ | 1866902199988125696 |
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| author | Qutlibika Abdurakhmonova |
| author_facet | Qutlibika Abdurakhmonova |
| contents | <p><em><span lang="EN-US">This study examines the prognostic significance of insulin resistance (IR) in nondiabetic patients with acute ischemic stroke. A cohort of 108 first-ever stroke patients without prior diabetes was evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). Patients were categorized into quartiles, with the highest quartile defined as insulin resistant, and followed for 12 months. IR was present in one-quarter of the cohort and was independently associated with increased mortality, higher recurrence rates, and poorer functional outcomes, even after adjusting for vascular risk factors. A clear dose-response relationship was observed, with higher HOMA-IR values correlating with progressively worse outcomes. These findings suggest that metabolic assessment, particularly identification of IR, should be integrated into routine stroke evaluation and secondary prevention strategies.</span></em></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17205081 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | INSULIN RESISTANCE AS A PREDICTOR OF PROGNOSIS IN NONDIABETIC PATIENTS WITH ACUTE ISCHEMIC STROKE Qutlibika Abdurakhmonova <p><em><span lang="EN-US">This study examines the prognostic significance of insulin resistance (IR) in nondiabetic patients with acute ischemic stroke. A cohort of 108 first-ever stroke patients without prior diabetes was evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). Patients were categorized into quartiles, with the highest quartile defined as insulin resistant, and followed for 12 months. IR was present in one-quarter of the cohort and was independently associated with increased mortality, higher recurrence rates, and poorer functional outcomes, even after adjusting for vascular risk factors. A clear dose-response relationship was observed, with higher HOMA-IR values correlating with progressively worse outcomes. These findings suggest that metabolic assessment, particularly identification of IR, should be integrated into routine stroke evaluation and secondary prevention strategies.</span></em></p> |
| title | INSULIN RESISTANCE AS A PREDICTOR OF PROGNOSIS IN NONDIABETIC PATIENTS WITH ACUTE ISCHEMIC STROKE |
| url | https://doi.org/10.5281/zenodo.17205081 |