Immunoglobulin-based therapeutic targeting in breast cancer for the treatment of liver metastasis: ACSM2B.
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| Natura: | Recurso digital |
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Zenodo
2025
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| _version_ | 1866901181737992192 |
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| author | Mamoor, Shahan |
| author_facet | Mamoor, Shahan |
| contents | <p dir="ltr">Metastasis is the major cause of death from cancer and metastasis to the liver is a frequent complication of both breast cancer and colorectal cancer, among the two most common cancers that afflict man (1-5). We recently utilized whole transcriptome technologies to define the full complement of differentially expressed kinases and phosphatases in HER2+ breast cancer: in the primary tumor, and in metastasis to the CNS (6-8). Here we utilize whole transcriptome technologies (9, 10) to conduct drug discovery by measuring total transcription in the liver metastases of humans with breast cancer, comparing the liver metastatic transcriptome to the primary tumor transcriptome. We identify here a therapeutic target based on its differential expression and up-regulation upon metastasis to the liver, ACSM2B, as a candidate therapeutic target for the medical management of liver metastasis using immunoglobulin-based reagents. </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17210399 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Immunoglobulin-based therapeutic targeting in breast cancer for the treatment of liver metastasis: ACSM2B. Mamoor, Shahan <p dir="ltr">Metastasis is the major cause of death from cancer and metastasis to the liver is a frequent complication of both breast cancer and colorectal cancer, among the two most common cancers that afflict man (1-5). We recently utilized whole transcriptome technologies to define the full complement of differentially expressed kinases and phosphatases in HER2+ breast cancer: in the primary tumor, and in metastasis to the CNS (6-8). Here we utilize whole transcriptome technologies (9, 10) to conduct drug discovery by measuring total transcription in the liver metastases of humans with breast cancer, comparing the liver metastatic transcriptome to the primary tumor transcriptome. We identify here a therapeutic target based on its differential expression and up-regulation upon metastasis to the liver, ACSM2B, as a candidate therapeutic target for the medical management of liver metastasis using immunoglobulin-based reagents. </p> |
| title | Immunoglobulin-based therapeutic targeting in breast cancer for the treatment of liver metastasis: ACSM2B. |
| url | https://doi.org/10.5281/zenodo.17210399 |