NECROTIZING FASCIITIS: - A NARRATIVE REVIEW OF EPIDEMIOLOGY, PATHOGENESIS, AND EMERGING THERAPIES IN WESTERN UGANDA
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| Formato: | Recurso digital |
| Lenguaje: | inglés |
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Zenodo
2025
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| _version_ | 1866901359513567232 |
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| author | Dr. Abdifatah Abdi Ali*1, Prof. Ahmed Kiswezi1, Dr. Abdullahi Osman Abdulle3, Dr. Demoz Abraha2, G.R. Neel2, Prof. Mai Abdalla Ali1 |
| author_facet | Dr. Abdifatah Abdi Ali*1, Prof. Ahmed Kiswezi1, Dr. Abdullahi Osman Abdulle3, Dr. Demoz Abraha2, G.R. Neel2, Prof. Mai Abdalla Ali1 |
| contents | <p><span>Necrotizing fasciitis (NF) is a rapidly progressing soft tissue infection with high mortality, characterized by fascial necrosis and systemic toxicity. Despite advances in surgical and antimicrobial therapies, NF remains a clinical challenge. This narrative review examines its epidemiology, pathogenesis, and emerging treatments. NF is primarily polymicrobial, with Group A Streptococcus (GAS) and mixed anaerobic-aerobic infections being most common. Pathogenesis involves bacterial virulence, immune evasion, and host susceptibility (e.g., diabetes, immunosuppression). Early surgical debridement and broad-spectrum antibiotics remain the cornerstone of treatment, while emerging therapies—such as immunomodulation (IVIG, hyperbaric oxygen), novel antimicrobials, and bacteriophage therapy—show promise. A multidisciplinary approach is essential, and further trials are needed to validate new treatments.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17221568 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | NECROTIZING FASCIITIS: - A NARRATIVE REVIEW OF EPIDEMIOLOGY, PATHOGENESIS, AND EMERGING THERAPIES IN WESTERN UGANDA Dr. Abdifatah Abdi Ali*1, Prof. Ahmed Kiswezi1, Dr. Abdullahi Osman Abdulle3, Dr. Demoz Abraha2, G.R. Neel2, Prof. Mai Abdalla Ali1 <p><span>Necrotizing fasciitis (NF) is a rapidly progressing soft tissue infection with high mortality, characterized by fascial necrosis and systemic toxicity. Despite advances in surgical and antimicrobial therapies, NF remains a clinical challenge. This narrative review examines its epidemiology, pathogenesis, and emerging treatments. NF is primarily polymicrobial, with Group A Streptococcus (GAS) and mixed anaerobic-aerobic infections being most common. Pathogenesis involves bacterial virulence, immune evasion, and host susceptibility (e.g., diabetes, immunosuppression). Early surgical debridement and broad-spectrum antibiotics remain the cornerstone of treatment, while emerging therapies—such as immunomodulation (IVIG, hyperbaric oxygen), novel antimicrobials, and bacteriophage therapy—show promise. A multidisciplinary approach is essential, and further trials are needed to validate new treatments.</span></p> |
| title | NECROTIZING FASCIITIS: - A NARRATIVE REVIEW OF EPIDEMIOLOGY, PATHOGENESIS, AND EMERGING THERAPIES IN WESTERN UGANDA |
| url | https://doi.org/10.5281/zenodo.17221568 |