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| Main Author: | |
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| Format: | Recurso digital |
| Language: | English |
| Published: |
Zenodo
2025
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| Online Access: | https://doi.org/10.5281/zenodo.17221568 |
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Table of Contents:
- <p><span>Necrotizing fasciitis (NF) is a rapidly progressing soft tissue infection with high mortality, characterized by fascial necrosis and systemic toxicity. Despite advances in surgical and antimicrobial therapies, NF remains a clinical challenge. This narrative review examines its epidemiology, pathogenesis, and emerging treatments. NF is primarily polymicrobial, with Group A Streptococcus (GAS) and mixed anaerobic-aerobic infections being most common. Pathogenesis involves bacterial virulence, immune evasion, and host susceptibility (e.g., diabetes, immunosuppression). Early surgical debridement and broad-spectrum antibiotics remain the cornerstone of treatment, while emerging therapies—such as immunomodulation (IVIG, hyperbaric oxygen), novel antimicrobials, and bacteriophage therapy—show promise. A multidisciplinary approach is essential, and further trials are needed to validate new treatments.</span></p>