From Neuropsychiatric Symptomatology to Oncological Diagnosis: Progression of Grade 2 to Grade 4 Cerebral Astrocytoma over a Four-Year Period and the Potential of AI in Precision Medicine - Figure 9
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2025
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| author | Andreea-Cătălina Moroșan Gabriel Dăscălescu Alin Ciobîcă Diana Maria Ichim George-Cătălin Moroșan |
| author_facet | Andreea-Cătălina Moroșan Gabriel Dăscălescu Alin Ciobîcă Diana Maria Ichim George-Cătălin Moroșan |
| contents | <div> </div> <div> <div>Microscopic analysis showed atypical tumour cells, pleomorphism, atypical mitoses, and vascular abnormalities, as illustrated in Figure 9 (panels A-D).</div> <div> <ul> <li>A) The tumour is very densely cellularised, being made up of medium-sized tumour cells, arranged in a diffuse pattern. The intratumoural vessels are numerous, richly branched and show glomeruloid endothelio-pericytic proliferation (black arrows). (H-E, eyepiece x10, objective x10)</li> </ul> </div> <div> <ul> <li> B) Tumour cells do not have cell borders, but have pleomorphic nuclei with coarse chromatin, with high mitotic activity (33 mitoses/high power field). Between these tumour cells are present, from place to place, extremely bulky tumour cells, with one or more irregular, hyperchromic nuclei, with a "monstrous" appearance, and sometimes with obvious eosinophilic cytoplasm (white arrow). (H-E, eyepiece x10, objective x20)</li> </ul> </div> <div> <ul> <li>C) The tumour is densely cellularised, being made up of cells with high cellular pleomorphism, some cells having a "monstrous" appearance (white arrow). It is noted the presence of an intratumoural vessel with marked endothelio-pericytic proliferation, which takes on a glomeruloid appearance (black arrow), and a microfocus of necrosis with nuclear debris, but without cell palisading in its periphery (yellow arrows) (HE, eyepiece x10, objective x20 )</li> </ul> </div> <div> <ul> <li>D) With a large objective, "monstrous"-looking tumour cells (white arrows), atypical mitosis (yellow arrow), and moderate endothelio-pericytic proliferation of intratumoural vessels (black arrows) are identified. (HE, eyepiece x10, objective x40).</li> </ul> </div> <div> </div> </div> |
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| publishDate | 2025 |
| publisher | Zenodo |
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| spellingShingle | From Neuropsychiatric Symptomatology to Oncological Diagnosis: Progression of Grade 2 to Grade 4 Cerebral Astrocytoma over a Four-Year Period and the Potential of AI in Precision Medicine - Figure 9 Andreea-Cătălina Moroșan Gabriel Dăscălescu Alin Ciobîcă Diana Maria Ichim George-Cătălin Moroșan <div> </div> <div> <div>Microscopic analysis showed atypical tumour cells, pleomorphism, atypical mitoses, and vascular abnormalities, as illustrated in Figure 9 (panels A-D).</div> <div> <ul> <li>A) The tumour is very densely cellularised, being made up of medium-sized tumour cells, arranged in a diffuse pattern. The intratumoural vessels are numerous, richly branched and show glomeruloid endothelio-pericytic proliferation (black arrows). (H-E, eyepiece x10, objective x10)</li> </ul> </div> <div> <ul> <li> B) Tumour cells do not have cell borders, but have pleomorphic nuclei with coarse chromatin, with high mitotic activity (33 mitoses/high power field). Between these tumour cells are present, from place to place, extremely bulky tumour cells, with one or more irregular, hyperchromic nuclei, with a "monstrous" appearance, and sometimes with obvious eosinophilic cytoplasm (white arrow). (H-E, eyepiece x10, objective x20)</li> </ul> </div> <div> <ul> <li>C) The tumour is densely cellularised, being made up of cells with high cellular pleomorphism, some cells having a "monstrous" appearance (white arrow). It is noted the presence of an intratumoural vessel with marked endothelio-pericytic proliferation, which takes on a glomeruloid appearance (black arrow), and a microfocus of necrosis with nuclear debris, but without cell palisading in its periphery (yellow arrows) (HE, eyepiece x10, objective x20 )</li> </ul> </div> <div> <ul> <li>D) With a large objective, "monstrous"-looking tumour cells (white arrows), atypical mitosis (yellow arrow), and moderate endothelio-pericytic proliferation of intratumoural vessels (black arrows) are identified. (HE, eyepiece x10, objective x40).</li> </ul> </div> <div> </div> </div> |
| title | From Neuropsychiatric Symptomatology to Oncological Diagnosis: Progression of Grade 2 to Grade 4 Cerebral Astrocytoma over a Four-Year Period and the Potential of AI in Precision Medicine - Figure 9 |
| url | https://doi.org/10.5281/zenodo.17231832 |