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| Autori principali: | , |
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| Natura: | Recurso digital |
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| Pubblicazione: |
Zenodo
2025
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| Accesso online: | https://doi.org/10.5281/zenodo.17235185 |
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Sommario:
- <p>This release contains scripts custom-written by Marta Graziano from <a href="https://ki.se/en/research/research-areas-centres-and-networks/research-groups/konstantinos-meletis-group#tab-research-focus">Meletis Lab</a> and Yuvarani Masarapu from <a href="https://www.spatialresearch.org/research-giacomello-lab/">Giacomello Lab</a> and used in the study <a href="https://www.biorxiv.org/content/10.1101/2025.09.09.675138v1">"A molecular atlas of cell types in the mouse and human parkinsonian striatum."</a>. The scripts from Giacomello Lab are also available on their <a href="https://github.com/giacomellolab/EarlyParkinsons_Striatum_Atlas.git">GitHub repository</a>.</p> <p>The scripts allow the user to (1) analyse and plot single-nucleus RNA sequencing (snRNA-seq) data for cell-specific transcriptomic changes in the striatum from Parkinson's Disease (PD) mouse models and human tissue; (2) analyse and plot spatial transcriptomics (ST) data to map regional vulnerabilities within the striatum, and perform differential expression for both snRNA-seq data and ST data; and (3) apply computational models for trajectory inference and pseudotime analyse using snRNA seq data.</p>