How Molecular Cooperation Drove Life's Emergence(Estimated Calculating Simulation)
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2025
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| _version_ | 1866901950281285632 |
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| author | Reza Hashemi |
| author_facet | Reza Hashemi |
| contents | <p>The origins of life represent one of science's greatest mysteries—how did inert chemistry transition to living biology? Our expanded computational framework demonstrates that Darwinian selection operates not just on individual molecules, but on entire molecular systems, driving the emergence of cooperation, specialization, and ultimately, cellular life. Through 200 replicate simulations of tri-molecular co-evolution (RNA, DNA, peptides, lipids, polyphosphates, and mineral catalysts), we show that cooperative complexes emerge spontaneously in 71.0% of systems, with protocell formation occurring in 44.5%. DNA maintains strong evolutionary dominance (68.7% overall, p < 10⁻²⁸) even within cooperative regimes, while positive cooperation-biomass correlations (r = 0.634) reveal that molecular synergy drives increased fitness. These results provide the first quantitative evidence that life's complexity emerges naturally through sequential evolutionary phase transitions.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17273742 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
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| spellingShingle | How Molecular Cooperation Drove Life's Emergence(Estimated Calculating Simulation) Reza Hashemi Chemical Darwinism, Matter World Hypothesis, Origin of Life, Prebiotic Chemistry, Computational Simulation, Hydrothermal Vents, Molecular Cooperation, Genetic Alphabet, Uracil Purge, Protocell Emergence <p>The origins of life represent one of science's greatest mysteries—how did inert chemistry transition to living biology? Our expanded computational framework demonstrates that Darwinian selection operates not just on individual molecules, but on entire molecular systems, driving the emergence of cooperation, specialization, and ultimately, cellular life. Through 200 replicate simulations of tri-molecular co-evolution (RNA, DNA, peptides, lipids, polyphosphates, and mineral catalysts), we show that cooperative complexes emerge spontaneously in 71.0% of systems, with protocell formation occurring in 44.5%. DNA maintains strong evolutionary dominance (68.7% overall, p < 10⁻²⁸) even within cooperative regimes, while positive cooperation-biomass correlations (r = 0.634) reveal that molecular synergy drives increased fitness. These results provide the first quantitative evidence that life's complexity emerges naturally through sequential evolutionary phase transitions.</p> |
| title | How Molecular Cooperation Drove Life's Emergence(Estimated Calculating Simulation) |
| topic | Chemical Darwinism, Matter World Hypothesis, Origin of Life, Prebiotic Chemistry, Computational Simulation, Hydrothermal Vents, Molecular Cooperation, Genetic Alphabet, Uracil Purge, Protocell Emergence |
| url | https://doi.org/10.5281/zenodo.17273742 |