| _version_ | 1866902187608637440 |
|---|---|
| author | Herath Mudiyanselage, Ruwini Madhushika Herath |
| author_facet | Herath Mudiyanselage, Ruwini Madhushika Herath |
| contents | <p>This record contains the full-text manuscript <strong>“Pediatric–Adult Divergence in Leukemia: Molecular Epidemiology, Risk-Adapted Therapy, and Late Effects,”</strong> authored by <strong>Ruwini Madhushika Herath Herath Mudiyanselage (Independent Bioinformatics Researcher)</strong>.</p> <p>The review synthesizes epidemiological, molecular, and clinical evidence from 1987–2025 to compare pediatric and adult leukemia across biological and therapeutic dimensions. It highlights the genomic evolution from fusion-driven pediatric disease to mutation-dense adult leukemia, emphasizing age-dependent therapeutic responses and survivorship outcomes.</p> <p>Key focus areas include:</p> <ul> <li> <p><strong>Global epidemiology</strong> and socioeconomic disparities in leukemia incidence and mortality.</p> </li> <li> <p><strong>Genetic and environmental etiologies,</strong> including inherited syndromes, radiation, and therapy-related risk.</p> </li> <li> <p><strong>Molecular pathogenesis</strong> and age-linked clonal hematopoiesis.</p> </li> <li> <p><strong>Risk-adapted therapies,</strong> including CAR-T cells, MRD-driven protocols, TKIs, and venetoclax-based regimens.</p> </li> <li> <p><strong>Long-term survivorship</strong> covering endocrine, cardiac, and psychosocial late effects.</p> </li> <li> <p><strong>Future directions</strong> in precision medicine, lifespan oncology, and equitable access to immunotherapies.</p> </li> </ul> <p>This work contributes to bridging pediatric and adult oncology paradigms by proposing integrated, age-adapted frameworks for leukemia care. All materials are shared under <strong>Creative Commons Attribution 4.0 International (CC BY 4.0)</strong> license.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17313337 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Pediatric–Adult Divergence in Leukemia: Molecular Epidemiology, Risk-Adapted Therapy, and Late Effects Herath Mudiyanselage, Ruwini Madhushika Herath <p>This record contains the full-text manuscript <strong>“Pediatric–Adult Divergence in Leukemia: Molecular Epidemiology, Risk-Adapted Therapy, and Late Effects,”</strong> authored by <strong>Ruwini Madhushika Herath Herath Mudiyanselage (Independent Bioinformatics Researcher)</strong>.</p> <p>The review synthesizes epidemiological, molecular, and clinical evidence from 1987–2025 to compare pediatric and adult leukemia across biological and therapeutic dimensions. It highlights the genomic evolution from fusion-driven pediatric disease to mutation-dense adult leukemia, emphasizing age-dependent therapeutic responses and survivorship outcomes.</p> <p>Key focus areas include:</p> <ul> <li> <p><strong>Global epidemiology</strong> and socioeconomic disparities in leukemia incidence and mortality.</p> </li> <li> <p><strong>Genetic and environmental etiologies,</strong> including inherited syndromes, radiation, and therapy-related risk.</p> </li> <li> <p><strong>Molecular pathogenesis</strong> and age-linked clonal hematopoiesis.</p> </li> <li> <p><strong>Risk-adapted therapies,</strong> including CAR-T cells, MRD-driven protocols, TKIs, and venetoclax-based regimens.</p> </li> <li> <p><strong>Long-term survivorship</strong> covering endocrine, cardiac, and psychosocial late effects.</p> </li> <li> <p><strong>Future directions</strong> in precision medicine, lifespan oncology, and equitable access to immunotherapies.</p> </li> </ul> <p>This work contributes to bridging pediatric and adult oncology paradigms by proposing integrated, age-adapted frameworks for leukemia care. All materials are shared under <strong>Creative Commons Attribution 4.0 International (CC BY 4.0)</strong> license.</p> |
| title | Pediatric–Adult Divergence in Leukemia: Molecular Epidemiology, Risk-Adapted Therapy, and Late Effects |
| url | https://doi.org/10.5281/zenodo.17313337 |