| _version_ | 1866902237327917056 |
|---|---|
| author | Golam Kibria Mollah Uttam Mondal Abhishek Choudhury |
| author_facet | Golam Kibria Mollah Uttam Mondal Abhishek Choudhury |
| contents | <p>Abstract <br>Introduction: Breast cancer continues to be the most common malignancy among women globally and <br>represents a significant cause of cancer-related mortality. Its heterogeneity, encompassing diverse molecular <br>subtypes and clinical behaviors, poses considerable challenges in diagnosis, prognostication, and treatment <br>selection. <br>Aims: To investigate the expression of PD-L1 and its association, if any, with the prognosis of breast carcinoma <br>of a patient. <br>Materials and Methods: The present study was an institution based descriptive, cross-sectional and <br>observational study. This Study was conducted fromJanuary 2020 to June 2021 at Medical College & Hospital, <br>Kolkata. Total 52 patients were included in this study. <br>Result: In our study of 52 breast carcinoma patients, PD-L1 expression was not significantly associated with <br>age, socioeconomic status, pain, ulceration, or tumor size. Invasive ductal carcinoma was the predominant <br>subtype (78.8%), followed by lobular (17.3%) and medullary carcinoma (3.8%). A strong association was <br>observed between PD-L1 positivity and HER2 expression, as 75% of HER2-positive cases were PD-L1 positive. <br>Importantly, PD-L1 positivity was linked to more aggressive disease features, including significantly higher <br>nodal involvement (mean 10.88 vs. 4.75, p < 0.0001) and increased distant metastasis, particularly to the lung <br>(31.3%) and bone (12.5%). <br>Conclusion: In conclusion, our study demonstrated that PD-L1 expression in breast carcinoma was not <br>significantly influenced by age, socioeconomic status, tumor size, pain, or ulceration. However, important <br>clinicopathological correlations were noted. PD-L1 expression showed a strong association with HER2 <br>positivity, suggesting a potential link between these biomarkers. </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17317807 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | A Clinico-Epidemiological Study of Tumour PD-LI Status in Breast Cancer Golam Kibria Mollah Uttam Mondal Abhishek Choudhury Breast cancer. PD-L1, HER2, Metastasis, Prognosis, Biomarker. <p>Abstract <br>Introduction: Breast cancer continues to be the most common malignancy among women globally and <br>represents a significant cause of cancer-related mortality. Its heterogeneity, encompassing diverse molecular <br>subtypes and clinical behaviors, poses considerable challenges in diagnosis, prognostication, and treatment <br>selection. <br>Aims: To investigate the expression of PD-L1 and its association, if any, with the prognosis of breast carcinoma <br>of a patient. <br>Materials and Methods: The present study was an institution based descriptive, cross-sectional and <br>observational study. This Study was conducted fromJanuary 2020 to June 2021 at Medical College & Hospital, <br>Kolkata. Total 52 patients were included in this study. <br>Result: In our study of 52 breast carcinoma patients, PD-L1 expression was not significantly associated with <br>age, socioeconomic status, pain, ulceration, or tumor size. Invasive ductal carcinoma was the predominant <br>subtype (78.8%), followed by lobular (17.3%) and medullary carcinoma (3.8%). A strong association was <br>observed between PD-L1 positivity and HER2 expression, as 75% of HER2-positive cases were PD-L1 positive. <br>Importantly, PD-L1 positivity was linked to more aggressive disease features, including significantly higher <br>nodal involvement (mean 10.88 vs. 4.75, p < 0.0001) and increased distant metastasis, particularly to the lung <br>(31.3%) and bone (12.5%). <br>Conclusion: In conclusion, our study demonstrated that PD-L1 expression in breast carcinoma was not <br>significantly influenced by age, socioeconomic status, tumor size, pain, or ulceration. However, important <br>clinicopathological correlations were noted. PD-L1 expression showed a strong association with HER2 <br>positivity, suggesting a potential link between these biomarkers. </p> |
| title | A Clinico-Epidemiological Study of Tumour PD-LI Status in Breast Cancer |
| topic | Breast cancer. PD-L1, HER2, Metastasis, Prognosis, Biomarker. |
| url | https://doi.org/10.5281/zenodo.17317807 |