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| Format: | Recurso digital |
| Language: | English |
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Zenodo
2025
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| Online Access: | https://doi.org/10.5281/zenodo.17374498 |
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| _version_ | 1866901756447817728 |
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| author | Melih Can Gül |
| author_facet | Melih Can Gül |
| contents | <p><strong><span lang="EN-US">Introduction</span></strong><span lang="EN-US"><br></span><span lang="TR">The introduction of chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized hematologic oncology, particularly in B-cell acute lymphoblastic leukemia and diffuse large B-cell lymphoma, where durable remissions have been achieved even in relapsed or refractory cases (1). Building on this unprecedented success, researchers have sought to extend CAR-T therapy to solid tumors. Gastrointestinal (GI) cancers, however, pose unique challenges. These include dense stromal barriers, an immunosuppressive tumor microenvironment (TME), heterogeneous antigen expression, and difficulties in ensuring adequate trafficking of effector T-cells (2,3). From the standpoint of a <strong>gastrointestinal cancer surgeon</strong>, the perioperative integration of CAR-T into multimodal strategies offers a compelling opportunity to enhance its translational potential and reshape GI oncology practice (4).</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17374498 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | CAR-T Cell Therapy in Gastrointestinal Surgical Oncology: Expanding Horizons beyond Hematologic Malignancies. Melih Can Gül <p><strong><span lang="EN-US">Introduction</span></strong><span lang="EN-US"><br></span><span lang="TR">The introduction of chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized hematologic oncology, particularly in B-cell acute lymphoblastic leukemia and diffuse large B-cell lymphoma, where durable remissions have been achieved even in relapsed or refractory cases (1). Building on this unprecedented success, researchers have sought to extend CAR-T therapy to solid tumors. Gastrointestinal (GI) cancers, however, pose unique challenges. These include dense stromal barriers, an immunosuppressive tumor microenvironment (TME), heterogeneous antigen expression, and difficulties in ensuring adequate trafficking of effector T-cells (2,3). From the standpoint of a <strong>gastrointestinal cancer surgeon</strong>, the perioperative integration of CAR-T into multimodal strategies offers a compelling opportunity to enhance its translational potential and reshape GI oncology practice (4).</span></p> |
| title | CAR-T Cell Therapy in Gastrointestinal Surgical Oncology: Expanding Horizons beyond Hematologic Malignancies. |
| url | https://doi.org/10.5281/zenodo.17374498 |