Synchronization Strategy for Antioxidant and Cryoprotectant Action in the Ex-Vivo Liver (Concept Note for Integrated Perfusion and Remote Activation)
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2025
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| _version_ | 1866902113662009344 |
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| author | Linchi, Giorgio Sergio Carlo |
| author_facet | Linchi, Giorgio Sergio Carlo |
| contents | <p><em>This concept note presents a strategy for the temporal synchronization of antioxidants and cryoprotectants in ex-vivo liver perfusion. By decoupling dose and timing, the approach enables homogeneous perfusion and simultaneous activation of antioxidants and ice recrystallization inhibitors through remote magneto-thermal or acoustic/photonic triggers. The “distribute-then-activate” logic reduces oxidative and osmotic stress, improves CPA entry, and minimizes recrystallization during warming, offering a scalable pathway for organ banking and nanowarming integration.</em></p> <p><em>Questo studio concettuale propone una strategia per sincronizzare temporalmente antiossidanti e crioprotettori nel fegato ex-vivo. Separando dose e tempistica, il metodo consente una perfusione omogenea e un’attivazione simultanea dei vettori tramite stimoli magneto-termici o acustico-fotonici, riducendo stress ossidativo/osmotico e ricristallizzazione durante il riscaldamento, con applicazioni dirette nella conservazione d’organo e nei sistemi di nanowarming.</em></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17445335 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Synchronization Strategy for Antioxidant and Cryoprotectant Action in the Ex-Vivo Liver (Concept Note for Integrated Perfusion and Remote Activation) Linchi, Giorgio Sergio Carlo cryopreservation ex-vivo perfusion ice recrystallization inhibitors nanowarming regenerative medicine <p><em>This concept note presents a strategy for the temporal synchronization of antioxidants and cryoprotectants in ex-vivo liver perfusion. By decoupling dose and timing, the approach enables homogeneous perfusion and simultaneous activation of antioxidants and ice recrystallization inhibitors through remote magneto-thermal or acoustic/photonic triggers. The “distribute-then-activate” logic reduces oxidative and osmotic stress, improves CPA entry, and minimizes recrystallization during warming, offering a scalable pathway for organ banking and nanowarming integration.</em></p> <p><em>Questo studio concettuale propone una strategia per sincronizzare temporalmente antiossidanti e crioprotettori nel fegato ex-vivo. Separando dose e tempistica, il metodo consente una perfusione omogenea e un’attivazione simultanea dei vettori tramite stimoli magneto-termici o acustico-fotonici, riducendo stress ossidativo/osmotico e ricristallizzazione durante il riscaldamento, con applicazioni dirette nella conservazione d’organo e nei sistemi di nanowarming.</em></p> |
| title | Synchronization Strategy for Antioxidant and Cryoprotectant Action in the Ex-Vivo Liver (Concept Note for Integrated Perfusion and Remote Activation) |
| topic | cryopreservation ex-vivo perfusion ice recrystallization inhibitors nanowarming regenerative medicine |
| url | https://doi.org/10.5281/zenodo.17445335 |