Single-cell profiling identifies a pathogenic Msx2⁺ VSMC subpopulation underlying aortic arch-specific vascular calcification
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2028
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| _version_ | 1866902033311727616 |
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| author | Zhu, Dongxing |
| author_facet | Zhu, Dongxing |
| contents | <p>This study investigates why the aortic arch is more prone to calcification than the descending aorta. Vascular calcification is a serious condition with no effective treatment, where blood vessel cells become similar to bone-forming cells. We used single-cell RNA sequencing on a mouse model of vitamin D-induced calcification to compare these two aortic regions. Our key discovery was a specific subpopulation of Msx2-positive vascular smooth muscle cells that is uniquely found in the aortic arch and appears to drive its increased calcification. This finding provides new insights into the cellular basis of regional calcification differences and could lead to new therapeutic targets.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17461594 |
| institution | Zenodo |
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| publishDate | 2028 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Single-cell profiling identifies a pathogenic Msx2⁺ VSMC subpopulation underlying aortic arch-specific vascular calcification Zhu, Dongxing <p>This study investigates why the aortic arch is more prone to calcification than the descending aorta. Vascular calcification is a serious condition with no effective treatment, where blood vessel cells become similar to bone-forming cells. We used single-cell RNA sequencing on a mouse model of vitamin D-induced calcification to compare these two aortic regions. Our key discovery was a specific subpopulation of Msx2-positive vascular smooth muscle cells that is uniquely found in the aortic arch and appears to drive its increased calcification. This finding provides new insights into the cellular basis of regional calcification differences and could lead to new therapeutic targets.</p> |
| title | Single-cell profiling identifies a pathogenic Msx2⁺ VSMC subpopulation underlying aortic arch-specific vascular calcification |
| url | https://doi.org/10.5281/zenodo.17461594 |