Simultaneous Estimation of Empagliflozin and Linagliptin in Bulk and Pharmaceutical Dosage Form by Reverse Phase-High Performance Liquid Chromatography
Fuente:
Zenodo
Salvato in:
| Autore principale: | |
|---|---|
| Natura: | Recurso digital |
| Pubblicazione: |
Zenodo
2025
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1866901209850314752 |
|---|---|
| author | Divya Jyothi*, Dr. S. Shobha Rani |
| author_facet | Divya Jyothi*, Dr. S. Shobha Rani |
| contents | <p><span lang="EN-US">A new, simple, precise, rapid, selective and stability reversed-phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated for the simultaneous quantification of Empagliflozin and Linagliptin in pure form and its pharmaceutical dosage form. The method is based on Phenomenex Gemini C18 (4.6×250mm) 5µ column. The column is maintained at 40°C throughout the analysis. The total run time is about 10 min. The method is validated for specificity, accuracy, precision and linearity, robustness and ruggedness, system suitability, limit of detection and limit of quantitation as per international conference of harmonization (ICH) Guidelines. inter-day precision (<2%) and robustness. The advantages of this method are good resolution with sharper peaks and sufficient precision. The results indicate that the method is suitable for the routine quality control testing of marketed tablet formulations.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17515692 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Simultaneous Estimation of Empagliflozin and Linagliptin in Bulk and Pharmaceutical Dosage Form by Reverse Phase-High Performance Liquid Chromatography Divya Jyothi*, Dr. S. Shobha Rani Empagliflozin and Linagliptin; Tablet doage forms; RP-HPLC; UV-VIS Detection; ICH Guidelines. <p><span lang="EN-US">A new, simple, precise, rapid, selective and stability reversed-phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated for the simultaneous quantification of Empagliflozin and Linagliptin in pure form and its pharmaceutical dosage form. The method is based on Phenomenex Gemini C18 (4.6×250mm) 5µ column. The column is maintained at 40°C throughout the analysis. The total run time is about 10 min. The method is validated for specificity, accuracy, precision and linearity, robustness and ruggedness, system suitability, limit of detection and limit of quantitation as per international conference of harmonization (ICH) Guidelines. inter-day precision (<2%) and robustness. The advantages of this method are good resolution with sharper peaks and sufficient precision. The results indicate that the method is suitable for the routine quality control testing of marketed tablet formulations.</span></p> |
| title | Simultaneous Estimation of Empagliflozin and Linagliptin in Bulk and Pharmaceutical Dosage Form by Reverse Phase-High Performance Liquid Chromatography |
| topic | Empagliflozin and Linagliptin; Tablet doage forms; RP-HPLC; UV-VIS Detection; ICH Guidelines. |
| url | https://doi.org/10.5281/zenodo.17515692 |