A COMPREHENSIVE OVERVIEW OF ALZHEIMER'S DISEASE: PATHOPHYSIOLOGY, DIAGNOSIS, AND THERAPEUTIC ADVANCES
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Zenodo
2025
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| author | Shivani L. Katpalliwar, Ankita S. Sarnaik, Swati P. Deshmukh |
| author_facet | Shivani L. Katpalliwar, Ankita S. Sarnaik, Swati P. Deshmukh |
| contents | <div> <p><em><span>Alzheimer’s disease; amyloid-β; tau; neuroinflammationAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and functional impairment. This review synthesizes currentunderstanding of AD pathogenesis, including amyloid-β aggregation, tau phosphorylation, neuroinflammation, synaptic dysfunction, and mitochondrial oxidative stress, alongside genetic and lifestyle risk factors. We compare classifications by onset, clinical stages, and biomarker profiles, evaluate pharmacologic and herbal therapeutic approaches, and examine advances in diagnostics and disease-modifying strategies. Emphasis is placed on translational research, challenges in therapeutic development, and future directions such as targeted immunotherapies, precision medicine, and improved drug delivery systems. Recommendations for research priorities and clinical management are presented.</span></em></p> <p><strong><em><span>Keywords:</span></em></strong><em><span> biomarkers; disease-modifying therapies; cognitive decline; precision medicine.</span></em></p> </div> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17592562 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | A COMPREHENSIVE OVERVIEW OF ALZHEIMER'S DISEASE: PATHOPHYSIOLOGY, DIAGNOSIS, AND THERAPEUTIC ADVANCES Shivani L. Katpalliwar, Ankita S. Sarnaik, Swati P. Deshmukh <div> <p><em><span>Alzheimer’s disease; amyloid-β; tau; neuroinflammationAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and functional impairment. This review synthesizes currentunderstanding of AD pathogenesis, including amyloid-β aggregation, tau phosphorylation, neuroinflammation, synaptic dysfunction, and mitochondrial oxidative stress, alongside genetic and lifestyle risk factors. We compare classifications by onset, clinical stages, and biomarker profiles, evaluate pharmacologic and herbal therapeutic approaches, and examine advances in diagnostics and disease-modifying strategies. Emphasis is placed on translational research, challenges in therapeutic development, and future directions such as targeted immunotherapies, precision medicine, and improved drug delivery systems. Recommendations for research priorities and clinical management are presented.</span></em></p> <p><strong><em><span>Keywords:</span></em></strong><em><span> biomarkers; disease-modifying therapies; cognitive decline; precision medicine.</span></em></p> </div> |
| title | A COMPREHENSIVE OVERVIEW OF ALZHEIMER'S DISEASE: PATHOPHYSIOLOGY, DIAGNOSIS, AND THERAPEUTIC ADVANCES |
| url | https://doi.org/10.5281/zenodo.17592562 |