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| Format: | Recurso digital |
| Language: | English |
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2025
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| Online Access: | https://doi.org/10.5281/zenodo.17625399 |
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| _version_ | 1866901990776242176 |
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| author | van der Merwe, Emile S. |
| author_facet | van der Merwe, Emile S. |
| contents | <p>This manuscript proposes that heme and hemoglobin are evolutionary descendants of the prebiotic redox-regulating systems described in the Proto-Liver Origin of Life (PLOL) framework.<br>Heme’s iron-porphyrin structure mirrors ancient mineral redox centers, and its chemistry reflects the same directional electron flow mechanisms proposed to stabilize early metabolism-like reactions. When embedded in a chiral protein pocket, heme acquires cooperative and regulatory properties, enabling hemoglobin to function as a distributed oxygen-control system across multicellular organisms.<br>This paper argues that hemoglobin retains structural and functional signatures of Earth’s earliest energy-stabilizing chemistry, creating a continuous lineage from prebiotic regulation → porphyrins → heme → hemoglobin → modern metabolic and physiological control (LBC framework).<br>The hypothesis yields testable predictions regarding porphyrin self-assembly, heme redox behavior, chirality-dependent binding dynamics, and ancestral hemoproteins.</p> <p>Companion Paper B01 - <strong><span>Iron–Sulfur Clusters as Evolutionary Bridges in the Proto-Liver Origin of Life (PLOL) V1 added 17 Nov 2025</span></strong></p> <p><strong>Keywords:</strong> heme evolution; hemoglobin; porphyrins; PLOL; redox regulation; prebiotic chemistry; oxygen transport; metabolic evolution; chirality; iron-sulfur chemistry.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17625399 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Heme & Hemoglobin as Biological Echoes of Prebiotic Redox Regulation: An Evolutionary Continuity from the Proto-Liver Origin of Life (PLOL) van der Merwe, Emile S. Heme Hemoglobin Porphyrins PLOL Redox Regulation Prebiotic Chemistry Early Metabolism Oxygen Transport Biological Evolution Redox Directionality Iron-Sulfur Chemistry Chirality L-amino Acids Cooperative Binding Energy Stabilization Liver–Brain Co-evolution (LBC) Evolutionary Bridges <p>This manuscript proposes that heme and hemoglobin are evolutionary descendants of the prebiotic redox-regulating systems described in the Proto-Liver Origin of Life (PLOL) framework.<br>Heme’s iron-porphyrin structure mirrors ancient mineral redox centers, and its chemistry reflects the same directional electron flow mechanisms proposed to stabilize early metabolism-like reactions. When embedded in a chiral protein pocket, heme acquires cooperative and regulatory properties, enabling hemoglobin to function as a distributed oxygen-control system across multicellular organisms.<br>This paper argues that hemoglobin retains structural and functional signatures of Earth’s earliest energy-stabilizing chemistry, creating a continuous lineage from prebiotic regulation → porphyrins → heme → hemoglobin → modern metabolic and physiological control (LBC framework).<br>The hypothesis yields testable predictions regarding porphyrin self-assembly, heme redox behavior, chirality-dependent binding dynamics, and ancestral hemoproteins.</p> <p>Companion Paper B01 - <strong><span>Iron–Sulfur Clusters as Evolutionary Bridges in the Proto-Liver Origin of Life (PLOL) V1 added 17 Nov 2025</span></strong></p> <p><strong>Keywords:</strong> heme evolution; hemoglobin; porphyrins; PLOL; redox regulation; prebiotic chemistry; oxygen transport; metabolic evolution; chirality; iron-sulfur chemistry.</p> |
| title | Heme & Hemoglobin as Biological Echoes of Prebiotic Redox Regulation: An Evolutionary Continuity from the Proto-Liver Origin of Life (PLOL) |
| topic | Heme Hemoglobin Porphyrins PLOL Redox Regulation Prebiotic Chemistry Early Metabolism Oxygen Transport Biological Evolution Redox Directionality Iron-Sulfur Chemistry Chirality L-amino Acids Cooperative Binding Energy Stabilization Liver–Brain Co-evolution (LBC) Evolutionary Bridges |
| url | https://doi.org/10.5281/zenodo.17625399 |