Cross-Study Harmonization and Machine Learning Pipeline for Predicting Melanoma Treatment Response

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Main Author: Al-sahly, Wafa
Format: Recurso digital
Language:English
Published: Zenodo 2025
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author Al-sahly, Wafa
author_facet Al-sahly, Wafa
contents <p><strong>We have 3 datasets </strong></p> <p>The first one, from GEO with accession no. GSE75299, is https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE75299.</p> <p>The second one, also from GEO with accession no. GSE65185, is at https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi.</p> <p>The third one, from EGA with study ID EGAD00001001306, is at https://ega-archive.org/datasets/EGAD00001001306.</p> <p><strong>purpose of the study</strong></p> <p>Develop a machine learning framework for predicting treatment response in cutaneous melanoma patients by integrating and harmonising raw RNA-seq data from multiple independent studies.</p> <p><strong>Methods, Software and version</strong></p> <p>nf-core RNA-seq pipeline by nextflow (Feature count)</p> <p>R code (DEGs), ML, DL, Feature selection, Figures, validation</p> <p> </p>
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publishDate 2025
publisher Zenodo
record_format zenodo
spellingShingle Cross-Study Harmonization and Machine Learning Pipeline for Predicting Melanoma Treatment Response
Al-sahly, Wafa
<p><strong>We have 3 datasets </strong></p> <p>The first one, from GEO with accession no. GSE75299, is https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE75299.</p> <p>The second one, also from GEO with accession no. GSE65185, is at https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi.</p> <p>The third one, from EGA with study ID EGAD00001001306, is at https://ega-archive.org/datasets/EGAD00001001306.</p> <p><strong>purpose of the study</strong></p> <p>Develop a machine learning framework for predicting treatment response in cutaneous melanoma patients by integrating and harmonising raw RNA-seq data from multiple independent studies.</p> <p><strong>Methods, Software and version</strong></p> <p>nf-core RNA-seq pipeline by nextflow (Feature count)</p> <p>R code (DEGs), ML, DL, Feature selection, Figures, validation</p> <p> </p>
title Cross-Study Harmonization and Machine Learning Pipeline for Predicting Melanoma Treatment Response
url https://doi.org/10.5281/zenodo.17632979