Rapid Evidence Synthesis: Protein-Depletion–Driven Postoperative Edema, Glycocalyx Dysfunction, and Diuretic Refractoriness
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| Natura: | Recurso digital |
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Zenodo
2025
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| _version_ | 1866901892033937408 |
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| author | Moore, Jaya |
| author_facet | Moore, Jaya |
| contents | <p>Rapid postoperative albumin decline, interstitial fluid accumulation, and diuretic refractoriness often co-occur in high-permeability states. Despite this, perioperative management paradigms frequently conceptualize postoperative edema as a simple fluid-excess problem rather than a protein-loss problem driven by increased capillary escape of albumin and glycocalyx degradation. Rapid Evidence Synthesis is an established methodology for supporting time-sensitive health-care decisions by summarizing heterogeneous evidence without the delays inherent to full systematic reviews. This working paper applies that method to the emerging clinical phenotype of postoperative protein-depletion edema.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17643651 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Rapid Evidence Synthesis: Protein-Depletion–Driven Postoperative Edema, Glycocalyx Dysfunction, and Diuretic Refractoriness Moore, Jaya <p>Rapid postoperative albumin decline, interstitial fluid accumulation, and diuretic refractoriness often co-occur in high-permeability states. Despite this, perioperative management paradigms frequently conceptualize postoperative edema as a simple fluid-excess problem rather than a protein-loss problem driven by increased capillary escape of albumin and glycocalyx degradation. Rapid Evidence Synthesis is an established methodology for supporting time-sensitive health-care decisions by summarizing heterogeneous evidence without the delays inherent to full systematic reviews. This working paper applies that method to the emerging clinical phenotype of postoperative protein-depletion edema.</p> |
| title | Rapid Evidence Synthesis: Protein-Depletion–Driven Postoperative Edema, Glycocalyx Dysfunction, and Diuretic Refractoriness |
| url | https://doi.org/10.5281/zenodo.17643651 |