Beyond the Tumor: The Locus Coeruleus–Vagus–Gut–Microbiome Axis as a Closed-Loop Target in Cancer
Fuente:
Zenodo
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Recurso digital |
| Veröffentlicht: |
Zenodo
2025
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1866901567199772672 |
|---|---|
| author | margolin, ido |
| author_facet | margolin, ido |
| contents | <p>Cancer is increasingly recognized not only as a disease of mutated cells but as a disorder of <strong>multi-scale networks</strong>: local tumor–immune interactions, systemic neuroendocrine and autonomic regulation, and the gut microbiome all contribute to disease progression and treatment response. Work in psychoneuroimmunology has shown that chronic stress, mediated in part by the locus coeruleus (LC) and sympathetic outflow, can suppress anti-tumor immunity and promote tumor growth. In parallel, studies of the vagus nerve and the "cholinergic anti-inflammatory reflex" suggest that augmenting vagal tone may reduce systemic inflammation and improve immune function. Finally, the gut microbiome has emerged as a critical modulator of responses to checkpoint inhibitors and other immunotherapies.</p> <p>This paper proposes a <strong>closed-loop neuro–immune architecture</strong> for oncology that integrates these strands into a single conceptual framework. We outline a high-level model in which (i) an LC-centered brain stress system, (ii) vagus nerve activity, (iii) gut–microbiome dynamics, and (iv) tumor–immune networks form a coupled system that can be monitored and, in principle, modulated. We introduce simple network and topological descriptors for trauma and resilience across this axis, suggest measurable proxies (heart-rate variability, sleep architecture, inflammatory and microbial markers, behavioral patterns), and sketch proof-of-concept experimental designs.</p> <p>The goal is not to propose a new therapy, but to articulate a <strong>systems-level language</strong> in which oncologists, immunologists, neuroscientists, and systems engineers can discuss how neuro–immune regulation and microbiome state might be incorporated into cancer care and survivorship research.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17658910 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Beyond the Tumor: The Locus Coeruleus–Vagus–Gut–Microbiome Axis as a Closed-Loop Target in Cancer margolin, ido cancer, psychoneuroimmunology, locus coeruleus, vagus nerve, gut microbiome, tumor microenvironment, closed-loop systems, systemic resilience <p>Cancer is increasingly recognized not only as a disease of mutated cells but as a disorder of <strong>multi-scale networks</strong>: local tumor–immune interactions, systemic neuroendocrine and autonomic regulation, and the gut microbiome all contribute to disease progression and treatment response. Work in psychoneuroimmunology has shown that chronic stress, mediated in part by the locus coeruleus (LC) and sympathetic outflow, can suppress anti-tumor immunity and promote tumor growth. In parallel, studies of the vagus nerve and the "cholinergic anti-inflammatory reflex" suggest that augmenting vagal tone may reduce systemic inflammation and improve immune function. Finally, the gut microbiome has emerged as a critical modulator of responses to checkpoint inhibitors and other immunotherapies.</p> <p>This paper proposes a <strong>closed-loop neuro–immune architecture</strong> for oncology that integrates these strands into a single conceptual framework. We outline a high-level model in which (i) an LC-centered brain stress system, (ii) vagus nerve activity, (iii) gut–microbiome dynamics, and (iv) tumor–immune networks form a coupled system that can be monitored and, in principle, modulated. We introduce simple network and topological descriptors for trauma and resilience across this axis, suggest measurable proxies (heart-rate variability, sleep architecture, inflammatory and microbial markers, behavioral patterns), and sketch proof-of-concept experimental designs.</p> <p>The goal is not to propose a new therapy, but to articulate a <strong>systems-level language</strong> in which oncologists, immunologists, neuroscientists, and systems engineers can discuss how neuro–immune regulation and microbiome state might be incorporated into cancer care and survivorship research.</p> |
| title | Beyond the Tumor: The Locus Coeruleus–Vagus–Gut–Microbiome Axis as a Closed-Loop Target in Cancer |
| topic | cancer, psychoneuroimmunology, locus coeruleus, vagus nerve, gut microbiome, tumor microenvironment, closed-loop systems, systemic resilience |
| url | https://doi.org/10.5281/zenodo.17658910 |