Review on Fluconazole: Properties and Analytical Methods for its Determination
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| Natura: | Recurso digital |
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Zenodo
2025
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| _version_ | 1866901768708816896 |
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| author | Dnyaneshwari Gaikwad*, Amol Gayke, Amol Jadhav, Komal Kute |
| author_facet | Dnyaneshwari Gaikwad*, Amol Gayke, Amol Jadhav, Komal Kute |
| contents | <p><span>Fluconazole is a triazole antifungal drug widely prescribed for systemic and mucocutaneous fungal infections. It acts by inhibiting fungal cytochrome P450-dependent 14α-demethylase, a key enzyme in ergosterol biosynthesis, leading to disruption of fungal cell membrane integrity. Due to its favorable pharmacokinetic profile, including high oral bioavailability and extensive tissue distribution, Fluconazole remains a first-line antifungal therapy. The accurate determination of Fluconazole in pharmaceutical formulations and biological matrices is critical for quality control, pharmacokinetic, and therapeutic drug monitoring purposes. This review highlights the physicochemical properties, pharmacological profile, and a comprehensive overview of analytical techniques employed for its quantification—such as spectrophotometry, HPLC, LC–MS/MS, GC, CE, and electrochemical methods. Each technique is discussed with respect to its principle, analytical performance, sample preparation, advantages, and limitations. Furthermore, recent advancements in miniaturized and high-sensitivity detection systems are emphasized</span><span>.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17667963 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Review on Fluconazole: Properties and Analytical Methods for its Determination Dnyaneshwari Gaikwad*, Amol Gayke, Amol Jadhav, Komal Kute Fluconazole, Triazole antifungal, HPLC, LC–MS/MS, Spectrophotometry, Analytical methods, Drug quantification, Method validation <p><span>Fluconazole is a triazole antifungal drug widely prescribed for systemic and mucocutaneous fungal infections. It acts by inhibiting fungal cytochrome P450-dependent 14α-demethylase, a key enzyme in ergosterol biosynthesis, leading to disruption of fungal cell membrane integrity. Due to its favorable pharmacokinetic profile, including high oral bioavailability and extensive tissue distribution, Fluconazole remains a first-line antifungal therapy. The accurate determination of Fluconazole in pharmaceutical formulations and biological matrices is critical for quality control, pharmacokinetic, and therapeutic drug monitoring purposes. This review highlights the physicochemical properties, pharmacological profile, and a comprehensive overview of analytical techniques employed for its quantification—such as spectrophotometry, HPLC, LC–MS/MS, GC, CE, and electrochemical methods. Each technique is discussed with respect to its principle, analytical performance, sample preparation, advantages, and limitations. Furthermore, recent advancements in miniaturized and high-sensitivity detection systems are emphasized</span><span>.</span></p> |
| title | Review on Fluconazole: Properties and Analytical Methods for its Determination |
| topic | Fluconazole, Triazole antifungal, HPLC, LC–MS/MS, Spectrophotometry, Analytical methods, Drug quantification, Method validation |
| url | https://doi.org/10.5281/zenodo.17667963 |