Solid Dispersion via Fusion Method for Improving Ivermectin Performance: A Critical Review
Fuente:
Zenodo
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | Recurso digital |
| Publicado: |
Zenodo
2025
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1866901703796719616 |
|---|---|
| author | Yasmin ShaiYasmin Shaik*, Irshad Ahmad, Shilpa Gangurdek*, Irshad Ahmad, Shilpa Gangurde |
| author_facet | Yasmin ShaiYasmin Shaik*, Irshad Ahmad, Shilpa Gangurdek*, Irshad Ahmad, Shilpa Gangurde |
| contents | <p><span>Ivermectin is a broad-spectrum antiparasitic agent widely used in human and veterinary medicine; however, its therapeutic potential is significantly limited by its very low aqueous solubility and consequent poor oral bioavailability. These physicochemical constraints present challenges in achieving optimal systemic exposure, necessitating higher doses that may increase the risk of adverse effects. Over the past decade, solid dispersion technology has emerged as one of the most effective formulation strategies for improving the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. Among various solid dispersion approaches, the fusion method stands out due to its simplicity, solvent-free nature, cost-effectiveness, and suitability for thermally stable compounds. This review provides a comprehensive overview of the principles, mechanisms, and advantages of solid dispersion systems, with particular emphasis on the fusion method as applied to ivermectin. It summarizes key carrier materials—such as PEGs, PVPs, poloxamers, and other hydrophilic polymers—and examines their roles in enhancing wettability, reducing crystallinity, and promoting molecular dispersion of ivermectin. The review also critically evaluates experimental findings from recent studies, highlighting improvements in dissolution behavior, pharmacokinetics, stability, and overall bioavailability achieved through fusion-based solid dispersions. Furthermore, challenges related to scale-up, polymer–drug compatibility, thermal stability, and long-term storage are discussed, along with emerging trends and future opportunities in formulation design. Overall, this review underscores the fusion-method solid dispersion technique as a promising and efficient strategy to overcome ivermectin’s solubility limitations and to enhance its therapeutic performance in oral drug delivery systems. </span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17678102 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Solid Dispersion via Fusion Method for Improving Ivermectin Performance: A Critical Review Yasmin ShaiYasmin Shaik*, Irshad Ahmad, Shilpa Gangurdek*, Irshad Ahmad, Shilpa Gangurde Ivermectin, Poor water solubility, Oral bioavailability, Solid dispersion, Fusion method, Hydrophilic polymers, Dissolution enhancement, Drug delivery systems, Amorphous formulations, pharmaceutical technology <p><span>Ivermectin is a broad-spectrum antiparasitic agent widely used in human and veterinary medicine; however, its therapeutic potential is significantly limited by its very low aqueous solubility and consequent poor oral bioavailability. These physicochemical constraints present challenges in achieving optimal systemic exposure, necessitating higher doses that may increase the risk of adverse effects. Over the past decade, solid dispersion technology has emerged as one of the most effective formulation strategies for improving the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. Among various solid dispersion approaches, the fusion method stands out due to its simplicity, solvent-free nature, cost-effectiveness, and suitability for thermally stable compounds. This review provides a comprehensive overview of the principles, mechanisms, and advantages of solid dispersion systems, with particular emphasis on the fusion method as applied to ivermectin. It summarizes key carrier materials—such as PEGs, PVPs, poloxamers, and other hydrophilic polymers—and examines their roles in enhancing wettability, reducing crystallinity, and promoting molecular dispersion of ivermectin. The review also critically evaluates experimental findings from recent studies, highlighting improvements in dissolution behavior, pharmacokinetics, stability, and overall bioavailability achieved through fusion-based solid dispersions. Furthermore, challenges related to scale-up, polymer–drug compatibility, thermal stability, and long-term storage are discussed, along with emerging trends and future opportunities in formulation design. Overall, this review underscores the fusion-method solid dispersion technique as a promising and efficient strategy to overcome ivermectin’s solubility limitations and to enhance its therapeutic performance in oral drug delivery systems. </span></p> |
| title | Solid Dispersion via Fusion Method for Improving Ivermectin Performance: A Critical Review |
| topic | Ivermectin, Poor water solubility, Oral bioavailability, Solid dispersion, Fusion method, Hydrophilic polymers, Dissolution enhancement, Drug delivery systems, Amorphous formulations, pharmaceutical technology |
| url | https://doi.org/10.5281/zenodo.17678102 |