| _version_ | 1866901722162528256 |
|---|---|
| author | T. Motwani*1, A. Mali2 |
| author_facet | T. Motwani*1, A. Mali2 |
| contents | <p><span>In the present investigation, ibuprofen, a commonly used non-steroidal anti-inflammatory drug (NSAID), was selected as a model compound to explore solubility enhancement through the hydrotropy technique. A synergistic blend of hydrotropic agents comprising 15% sodium salicylate, 5% niacinamide, 5% sodium citrate, and 5% sodium acetate was employed for this purpose. The mixed hydrotropic system demonstrated a remarkable increase in solubility, exhibiting more than a forty-fold enhancement compared to the solubility of ibuprofen in distilled water. This significant improvement confirms the potential of hydrotropic combinations as an efficient and environmentally safer alternative to conventional solubilization methods. Furthermore, the hydrotropy assisted solubilization was effectively utilized in the titrimetric estimation of ibuprofen, eliminating the requirement for organic solvents that are often hazardous, expensive, and environmentally unfriendly. The analytical results obtained using the proposed method were in excellent agreement with those reported in the Indian Pharmacopoeia, confirming the accuracy and reliability of the developed approach. Importantly, the presence of the hydrotropic agents did not interfere with the analytical procedure, ensuring the precision of the estimation. Overall, the study demonstrates that the mixed hydrotropic system provides a simple, safe, economical, and eco-friendly method for enhancing the solubility and analytical determination of poorly water-soluble drugs like ibuprofen, potentially extending its application to other BCS Class II drugs.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17723506 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Green And Efficient Estimation of Ibuprofen Via Mixed Hydrotropy Approach T. Motwani*1, A. Mali2 Mixed Hydrotropy, Ibuprofen, Titrimetry, Solubility Enhancement <p><span>In the present investigation, ibuprofen, a commonly used non-steroidal anti-inflammatory drug (NSAID), was selected as a model compound to explore solubility enhancement through the hydrotropy technique. A synergistic blend of hydrotropic agents comprising 15% sodium salicylate, 5% niacinamide, 5% sodium citrate, and 5% sodium acetate was employed for this purpose. The mixed hydrotropic system demonstrated a remarkable increase in solubility, exhibiting more than a forty-fold enhancement compared to the solubility of ibuprofen in distilled water. This significant improvement confirms the potential of hydrotropic combinations as an efficient and environmentally safer alternative to conventional solubilization methods. Furthermore, the hydrotropy assisted solubilization was effectively utilized in the titrimetric estimation of ibuprofen, eliminating the requirement for organic solvents that are often hazardous, expensive, and environmentally unfriendly. The analytical results obtained using the proposed method were in excellent agreement with those reported in the Indian Pharmacopoeia, confirming the accuracy and reliability of the developed approach. Importantly, the presence of the hydrotropic agents did not interfere with the analytical procedure, ensuring the precision of the estimation. Overall, the study demonstrates that the mixed hydrotropic system provides a simple, safe, economical, and eco-friendly method for enhancing the solubility and analytical determination of poorly water-soluble drugs like ibuprofen, potentially extending its application to other BCS Class II drugs.</span></p> |
| title | Green And Efficient Estimation of Ibuprofen Via Mixed Hydrotropy Approach |
| topic | Mixed Hydrotropy, Ibuprofen, Titrimetry, Solubility Enhancement |
| url | https://doi.org/10.5281/zenodo.17723506 |