Technoprocess diagram for parasympathetic regulatory tablet production
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2025
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| author | Argota Pérez, George Pecho Riveros, Rossy Liset Bolívar Espinoza, Néstor Enríquez Mamani, Vitaliano Marín Paucará, Marín Paucará Escobar Mamani, Fortunato Celi Saavedra, Luis Tadeo Argota Pérez, Yadira |
| author_facet | Argota Pérez, George Pecho Riveros, Rossy Liset Bolívar Espinoza, Néstor Enríquez Mamani, Vitaliano Marín Paucará, Marín Paucará Escobar Mamani, Fortunato Celi Saavedra, Luis Tadeo Argota Pérez, Yadira |
| contents | <p><span>The validation of the process-based technological package for the Functional Formulation of Microencapsulated Tablets with Andean Regulatory Metabolites for Parasympathetic Axis Modulation reaches Technology Readiness Level 5 (TRL 5) through the systematic integration of two complementary phases: the documentary-conceptual phase and the experimental-practical phase. In the documentary or conceptual-laboratory phase, the technological process was structured using flow diagrams, functional models, and manual simulations that precisely represented the critical stages: selective extraction of metabolites from Andean roots, leaves, and stems; thermochemical stabilization; protective microencapsulation; functional compression; and release validation. This phase enabled the correction of inconsistencies, definition of operational parameters, standardization of inputs (maltodextrins, alginates, compressible excipients), and the establishment of reproducibility criteria associated with phytoactive stability and the expected controlled-release kinetics. The experimental or practical-laboratory phase extended the conceptual models into technical-fidelity assessments through bench-scale trials, pilot batches, and proxy physiological simulations. Indicators such as extraction efficiency, microcapsule integrity, thermal stability, controlled release performance, and persistence of neuroactive metabolites were evaluated. Likewise, inter-batch reproducibility, robustness of critical parameters, and reliability of the compression process were verified under controlled conditions, identifying and mitigating bottlenecks related to drying, coating, and humidity. The convergence of both phases ensures conceptual coherence, experimental stability, and verifiable repeatability, demonstrating that the process operates consistently in relevant environments and fully justifying its classification at TRL 5, with appropriate readiness for transition to pre-operational in-line validation (TRL 6).</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17727153 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Technoprocess diagram for parasympathetic regulatory tablet production Argota Pérez, George Pecho Riveros, Rossy Liset Bolívar Espinoza, Néstor Enríquez Mamani, Vitaliano Marín Paucará, Marín Paucará Escobar Mamani, Fortunato Celi Saavedra, Luis Tadeo Argota Pérez, Yadira <p><span>The validation of the process-based technological package for the Functional Formulation of Microencapsulated Tablets with Andean Regulatory Metabolites for Parasympathetic Axis Modulation reaches Technology Readiness Level 5 (TRL 5) through the systematic integration of two complementary phases: the documentary-conceptual phase and the experimental-practical phase. In the documentary or conceptual-laboratory phase, the technological process was structured using flow diagrams, functional models, and manual simulations that precisely represented the critical stages: selective extraction of metabolites from Andean roots, leaves, and stems; thermochemical stabilization; protective microencapsulation; functional compression; and release validation. This phase enabled the correction of inconsistencies, definition of operational parameters, standardization of inputs (maltodextrins, alginates, compressible excipients), and the establishment of reproducibility criteria associated with phytoactive stability and the expected controlled-release kinetics. The experimental or practical-laboratory phase extended the conceptual models into technical-fidelity assessments through bench-scale trials, pilot batches, and proxy physiological simulations. Indicators such as extraction efficiency, microcapsule integrity, thermal stability, controlled release performance, and persistence of neuroactive metabolites were evaluated. Likewise, inter-batch reproducibility, robustness of critical parameters, and reliability of the compression process were verified under controlled conditions, identifying and mitigating bottlenecks related to drying, coating, and humidity. The convergence of both phases ensures conceptual coherence, experimental stability, and verifiable repeatability, demonstrating that the process operates consistently in relevant environments and fully justifying its classification at TRL 5, with appropriate readiness for transition to pre-operational in-line validation (TRL 6).</span></p> |
| title | Technoprocess diagram for parasympathetic regulatory tablet production |
| url | https://doi.org/10.5281/zenodo.17727153 |