| _version_ | 1866902025007005696 |
|---|---|
| author | Sapunarova K. Bivolarski I. |
| author_facet | Sapunarova K. Bivolarski I. |
| contents | <p><span lang="EN-US">In the article authors represent an analytical review of current evidence on infectious complications in β-thalassemia, integrating data from pathophysiological research, clinical studies, and recent international guidelines. Infections remain a major cause of morbidity and mortality despite advances in therapy in beta- tjassemia patients. Chronic anemia, iron overload, and splenic dysfunction lead to significant disturbances in innate and adaptive immunity. Functional hyposplenism or splenectomy increases susceptibility to encapsulated bacteria, while excess iron promotes oxidative stress and macrophage dysfunction, facilitating siderophilic infections. Chronic transfusions expose patients to transfusion-transmitted viruses, and chelation therapy—particularly with deferoxamine—may further modify infection risk. The review emphasizes evidence-based prevention through vaccination, antibiotic prophylaxis, careful chelation, monitoring, and patient education. By summarizing current data and guideline recommendations, we highlight the importance of integrated infection control as a key component of modern β-thalassemia management.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17769772 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | INFECTIONS AND Β-THALASSEMIA Sapunarova K. Bivolarski I. β-thalassemia, infections, splenectomy, iron overload, chelation therapy, immune dysfunction, prevention. <p><span lang="EN-US">In the article authors represent an analytical review of current evidence on infectious complications in β-thalassemia, integrating data from pathophysiological research, clinical studies, and recent international guidelines. Infections remain a major cause of morbidity and mortality despite advances in therapy in beta- tjassemia patients. Chronic anemia, iron overload, and splenic dysfunction lead to significant disturbances in innate and adaptive immunity. Functional hyposplenism or splenectomy increases susceptibility to encapsulated bacteria, while excess iron promotes oxidative stress and macrophage dysfunction, facilitating siderophilic infections. Chronic transfusions expose patients to transfusion-transmitted viruses, and chelation therapy—particularly with deferoxamine—may further modify infection risk. The review emphasizes evidence-based prevention through vaccination, antibiotic prophylaxis, careful chelation, monitoring, and patient education. By summarizing current data and guideline recommendations, we highlight the importance of integrated infection control as a key component of modern β-thalassemia management.</span></p> |
| title | INFECTIONS AND Β-THALASSEMIA |
| topic | β-thalassemia, infections, splenectomy, iron overload, chelation therapy, immune dysfunction, prevention. |
| url | https://doi.org/10.5281/zenodo.17769772 |