CHANGES IN THE ACTIVITY OF SMALL INTESTINAL DISACCHARIDASES IN DIABETES MELLITUS
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2025
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| author | Olimova, Shohsanam Mazalova, Azizaxon Sobirova, Marvarida |
| author_facet | Olimova, Shohsanam Mazalova, Azizaxon Sobirova, Marvarida |
| contents | <p><span lang="EN-US">Diabetes mellitus (DM) is a chronic metabolic disease associated with insufficient insulin secretion or impaired insulin action. DM not only disrupts the metabolism of carbohydrates, fats, and proteins but also seriously affects the function of the digestive system. The aim of this article is to study the mechanisms and clinical significance of decreased activity of key disaccharidase enzymes (lactase, sucrase, maltase) located in the small intestine of patients with DM. Research results indicate that hyperglycemia, oxidative stress, and tissue insulin resistance lead to morphological and functional impairments of the small intestinal epithelium, which causes a decrease in enzyme activity and, consequently, impaired digestion of disaccharides (disaccharidase deficiency). This condition leads to the exacerbation of gastrointestinal symptoms such as abdominal pain, diarrhea, and flatulence in patients.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17783998 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | CHANGES IN THE ACTIVITY OF SMALL INTESTINAL DISACCHARIDASES IN DIABETES MELLITUS Olimova, Shohsanam Mazalova, Azizaxon Sobirova, Marvarida Diabetes mellitus, small intestine, disaccharidases, lactase, sucrase, maltase, disaccharidase deficiency, hyperglycemia. <p><span lang="EN-US">Diabetes mellitus (DM) is a chronic metabolic disease associated with insufficient insulin secretion or impaired insulin action. DM not only disrupts the metabolism of carbohydrates, fats, and proteins but also seriously affects the function of the digestive system. The aim of this article is to study the mechanisms and clinical significance of decreased activity of key disaccharidase enzymes (lactase, sucrase, maltase) located in the small intestine of patients with DM. Research results indicate that hyperglycemia, oxidative stress, and tissue insulin resistance lead to morphological and functional impairments of the small intestinal epithelium, which causes a decrease in enzyme activity and, consequently, impaired digestion of disaccharides (disaccharidase deficiency). This condition leads to the exacerbation of gastrointestinal symptoms such as abdominal pain, diarrhea, and flatulence in patients.</span></p> |
| title | CHANGES IN THE ACTIVITY OF SMALL INTESTINAL DISACCHARIDASES IN DIABETES MELLITUS |
| topic | Diabetes mellitus, small intestine, disaccharidases, lactase, sucrase, maltase, disaccharidase deficiency, hyperglycemia. |
| url | https://doi.org/10.5281/zenodo.17783998 |