Title: Zoonotic Spillover: Mechanistic Pathways, Environmental Catalysts, and One Health Strategies for Emerging Infectious Disease Prevention
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| Natura: | Recurso digital |
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Zenodo
2025
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| author | N.N. Parmar1*, Y.S. Parmar2, R.J. Patel1, M.M Goswami3 |
| author_facet | N.N. Parmar1*, Y.S. Parmar2, R.J. Patel1, M.M Goswami3 |
| contents | <p><strong>Zoonotic spillover</strong>—the transfer of pathogens from animals to humans—is a multifactorial process influenced by ecological disruption, pathogen evolution, host immune dynamics, and human behavior. Increasing land-use change, biodiversity loss, agricultural intensification, urban expansion, and climate variability are driving closer interaction among humans, domestic animals, and wildlife. Molecular evidence shows that cross-species transmission often involves viral adaptation, particularly through recombination or reassortment in intermediate hosts. Host susceptibility further depends on genetic polymorphisms, immune status, and risky sociocultural practices such as wildlife trade and unregulated livestock handling. Recent pandemics, including COVID-19, demonstrate the global implications of spillover and emphasize the need for proactive, integrated surveillance systems. This review synthesizes mechanistic pathways and major risk drivers, evaluates predictive modeling approaches, and proposes an advanced One Health strategy for prevention. Future priorities include AI-based early detection, microbiome profiling, genomically informed risk assessment, and climate-resilient outbreak forecasting.</p> <p> </p> <div> </div> <p> </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17846826 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Title: Zoonotic Spillover: Mechanistic Pathways, Environmental Catalysts, and One Health Strategies for Emerging Infectious Disease Prevention N.N. Parmar1*, Y.S. Parmar2, R.J. Patel1, M.M Goswami3 <p><strong>Zoonotic spillover</strong>—the transfer of pathogens from animals to humans—is a multifactorial process influenced by ecological disruption, pathogen evolution, host immune dynamics, and human behavior. Increasing land-use change, biodiversity loss, agricultural intensification, urban expansion, and climate variability are driving closer interaction among humans, domestic animals, and wildlife. Molecular evidence shows that cross-species transmission often involves viral adaptation, particularly through recombination or reassortment in intermediate hosts. Host susceptibility further depends on genetic polymorphisms, immune status, and risky sociocultural practices such as wildlife trade and unregulated livestock handling. Recent pandemics, including COVID-19, demonstrate the global implications of spillover and emphasize the need for proactive, integrated surveillance systems. This review synthesizes mechanistic pathways and major risk drivers, evaluates predictive modeling approaches, and proposes an advanced One Health strategy for prevention. Future priorities include AI-based early detection, microbiome profiling, genomically informed risk assessment, and climate-resilient outbreak forecasting.</p> <p> </p> <div> </div> <p> </p> |
| title | Title: Zoonotic Spillover: Mechanistic Pathways, Environmental Catalysts, and One Health Strategies for Emerging Infectious Disease Prevention |
| url | https://doi.org/10.5281/zenodo.17846826 |