Stimuli-Responsive in Situ Gelling System for Ocular Drug Delivery: From Polymer Design to Clinical Translation
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2025
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| _version_ | 1866901248722075648 |
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| author | Sapna Yadav*, Nakul Gupta, Nitin Kumar, Adiba Rahman, Bipasha Ray |
| author_facet | Sapna Yadav*, Nakul Gupta, Nitin Kumar, Adiba Rahman, Bipasha Ray |
| contents | <p><span>A potential approach to ocular medication delivery, in situ gelling devices overcome the drawbacks of traditional eye drops, namely their limited bioavailability and quick drainage. These systems provide extended drug retention on the ocular surface by changing from a liquid to a gel when exposed to particular physiological circumstances such as pH, temperature, or ionic strength. The necessity for frequent administration is reduced and therapeutic efficacy is increased by this sustained release mechanism. In situ systems employ temperature-sensitive, pH-sensitive, and ion-activated gelation mechanisms. When ion-sensitive systems, including those that use sodium alginate and gellan gum, come into touch with divalent ions, they gel. While pH-sensitive polymers, like chitosan, gel in response to variations in ocular pH, temperature-sensitive polymers, like poly(N-isopropylacrylamide), gel at body temperature. These systems are designed to satisfy particular requirements for drug delivery. Both synthetic polymers like poloxamers and poly(N-isopropylacrylamide) and natural biopolymers like gellan gum, sodium alginate, and chitosan are frequently utilized in in situ gelling systems. These polymers were chosen because of their regulated drug delivery capabilities, gelling qualities, and biocompatibility. In situ gelling systems have been used in clinical settings to treat a range of eye disorders, such as glaucoma, post-operative inflammation, conjunctivitis, and dry eye syndrome. They offer better patient compliance, decreased drug waste, and increased drug retention. Notwithstanding these benefits, issues with stability, eye discomfort, and regulatory approval still exist. It is anticipated that developments in formulation techniques and stimuli-responsive polymers will increase the effectiveness of in situ gelling systems in ocular medication administration.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17868060 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
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| spellingShingle | Stimuli-Responsive in Situ Gelling System for Ocular Drug Delivery: From Polymer Design to Clinical Translation Sapna Yadav*, Nakul Gupta, Nitin Kumar, Adiba Rahman, Bipasha Ray In situ gel, stimuli-responsive, polymers, mucoadhesion. <p><span>A potential approach to ocular medication delivery, in situ gelling devices overcome the drawbacks of traditional eye drops, namely their limited bioavailability and quick drainage. These systems provide extended drug retention on the ocular surface by changing from a liquid to a gel when exposed to particular physiological circumstances such as pH, temperature, or ionic strength. The necessity for frequent administration is reduced and therapeutic efficacy is increased by this sustained release mechanism. In situ systems employ temperature-sensitive, pH-sensitive, and ion-activated gelation mechanisms. When ion-sensitive systems, including those that use sodium alginate and gellan gum, come into touch with divalent ions, they gel. While pH-sensitive polymers, like chitosan, gel in response to variations in ocular pH, temperature-sensitive polymers, like poly(N-isopropylacrylamide), gel at body temperature. These systems are designed to satisfy particular requirements for drug delivery. Both synthetic polymers like poloxamers and poly(N-isopropylacrylamide) and natural biopolymers like gellan gum, sodium alginate, and chitosan are frequently utilized in in situ gelling systems. These polymers were chosen because of their regulated drug delivery capabilities, gelling qualities, and biocompatibility. In situ gelling systems have been used in clinical settings to treat a range of eye disorders, such as glaucoma, post-operative inflammation, conjunctivitis, and dry eye syndrome. They offer better patient compliance, decreased drug waste, and increased drug retention. Notwithstanding these benefits, issues with stability, eye discomfort, and regulatory approval still exist. It is anticipated that developments in formulation techniques and stimuli-responsive polymers will increase the effectiveness of in situ gelling systems in ocular medication administration.</span></p> |
| title | Stimuli-Responsive in Situ Gelling System for Ocular Drug Delivery: From Polymer Design to Clinical Translation |
| topic | In situ gel, stimuli-responsive, polymers, mucoadhesion. |
| url | https://doi.org/10.5281/zenodo.17868060 |