Predictive Bioharmonics: Predicting Embryo Stability Before Fertilization (A Pre-Pilot Study on Real-World Data)
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| Natura: | Recurso digital |
| Lingua: | inglese |
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Zenodo
2025
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| _version_ | 1866901552226107392 |
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| author | Fries, Tess |
| author_facet | Fries, Tess |
| contents | <p dir="ltr">In this pre-pilot study, I use real-world data to show that embryo stability is mathematically predictable before fertilization. Early embryo morphokinetics, specifically the cleavage intervals cc2 and s2, carry a direct dynamical signature of how well the oocyte and sperm matched. Using a PB-derived mismatch metric, I demonstrate that these timings reveal the underlying interaction between the gametes and that embryo stability can be inferred before an embryo exists. The analysis further shows that the embryo expresses the dynamical difference—not the sum—of the oocyte and spermatozoon. </p> <p dir="ltr">These findings open the possibility of pre-conception prediction of embryo stability, with implications for gamete selection, IVF efficiency, reduced patient burden, and early identification of instability prior to embryo formation. </p> <p dir="ltr">By using PB as a mathematical dynamic analysis, the individual dynamics of both egg and sperm can be evaluated to predict embryo stability. Furthermore, any mismatch in stability can be directly corrected in the IVF clinic—on the egg, the sperm, or the embryo—based on their dynamical signatures. </p> <p dir="ltr">The implications call for an immediate pilot study.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17871283 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Predictive Bioharmonics: Predicting Embryo Stability Before Fertilization (A Pre-Pilot Study on Real-World Data) Fries, Tess Predictive Bioharmonics embryo stability fertility infertility gamete interaction dynamics morphokinetics IVF <p dir="ltr">In this pre-pilot study, I use real-world data to show that embryo stability is mathematically predictable before fertilization. Early embryo morphokinetics, specifically the cleavage intervals cc2 and s2, carry a direct dynamical signature of how well the oocyte and sperm matched. Using a PB-derived mismatch metric, I demonstrate that these timings reveal the underlying interaction between the gametes and that embryo stability can be inferred before an embryo exists. The analysis further shows that the embryo expresses the dynamical difference—not the sum—of the oocyte and spermatozoon. </p> <p dir="ltr">These findings open the possibility of pre-conception prediction of embryo stability, with implications for gamete selection, IVF efficiency, reduced patient burden, and early identification of instability prior to embryo formation. </p> <p dir="ltr">By using PB as a mathematical dynamic analysis, the individual dynamics of both egg and sperm can be evaluated to predict embryo stability. Furthermore, any mismatch in stability can be directly corrected in the IVF clinic—on the egg, the sperm, or the embryo—based on their dynamical signatures. </p> <p dir="ltr">The implications call for an immediate pilot study.</p> |
| title | Predictive Bioharmonics: Predicting Embryo Stability Before Fertilization (A Pre-Pilot Study on Real-World Data) |
| topic | Predictive Bioharmonics embryo stability fertility infertility gamete interaction dynamics morphokinetics IVF |
| url | https://doi.org/10.5281/zenodo.17871283 |