| _version_ | 1866901337992593408 |
|---|---|
| author | Jyoti Singh*, Nadeem A. Farooqui, Nayany Sharma, Nimita Manocha |
| author_facet | Jyoti Singh*, Nadeem A. Farooqui, Nayany Sharma, Nimita Manocha |
| contents | <p><span>NDDS technologies are transforming the therapeutic application of potent antioxidant N-acetylcysteine (NAC), a potent anti-inflammatory agent. These technologies improve NAC's pharmacokinetic profiles, focusing on selective activity areas and enabling sustained release. They include liposomes, hydrogels, microspheres, nanoparticles, and nanostructured carriers, aiming to increase bioavailability, protect NAC from degradation, and deliver controlled release for maximum therapeutic benefits and minimal side effects. The therapeutic potential of nanoparticles (NAC) in neurological diseases is being explored, with the potential to inhibit inflammatory pathways, neutralize reactive oxygen species, and affect cell survival. Technological developments, such as targeted delivery platforms and stimuli-responsive devices, are being explored to enhance NAC therapies. Personalized medicine is also crucial for maximizing NAC therapies. This review discusses the therapeutic potential of NAC-loaded NDDS, highlighting the need for clinical trials, preclinical studies, and Good Manufacturing Practice compliance. It also highlights the potential for NAC in NDDS to expand into other therapeutic fields, despite challenges in regulatory approval and patient acceptance.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17871356 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | A Review on Application of Novel Drug Delivery Systems for the N-Acetylcysteine Jyoti Singh*, Nadeem A. Farooqui, Nayany Sharma, Nimita Manocha N-acetylcysteine (NAC); novel drug delivery systems (NDDS); nanoparticles; targeted drug delivery; antioxidant therapy <p><span>NDDS technologies are transforming the therapeutic application of potent antioxidant N-acetylcysteine (NAC), a potent anti-inflammatory agent. These technologies improve NAC's pharmacokinetic profiles, focusing on selective activity areas and enabling sustained release. They include liposomes, hydrogels, microspheres, nanoparticles, and nanostructured carriers, aiming to increase bioavailability, protect NAC from degradation, and deliver controlled release for maximum therapeutic benefits and minimal side effects. The therapeutic potential of nanoparticles (NAC) in neurological diseases is being explored, with the potential to inhibit inflammatory pathways, neutralize reactive oxygen species, and affect cell survival. Technological developments, such as targeted delivery platforms and stimuli-responsive devices, are being explored to enhance NAC therapies. Personalized medicine is also crucial for maximizing NAC therapies. This review discusses the therapeutic potential of NAC-loaded NDDS, highlighting the need for clinical trials, preclinical studies, and Good Manufacturing Practice compliance. It also highlights the potential for NAC in NDDS to expand into other therapeutic fields, despite challenges in regulatory approval and patient acceptance.</span></p> |
| title | A Review on Application of Novel Drug Delivery Systems for the N-Acetylcysteine |
| topic | N-acetylcysteine (NAC); novel drug delivery systems (NDDS); nanoparticles; targeted drug delivery; antioxidant therapy |
| url | https://doi.org/10.5281/zenodo.17871356 |