Microbial Enzymatic Cycle (MEC) & The Origin of Physiological Architecture: A Mechanistic Foundation for the Microbial Integration Theory (MIT)
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| Natura: | Recurso digital |
| Lingua: | inglese |
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Zenodo
2025
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| _version_ | 1866901439857557504 |
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| author | Hendiyani Irjanti 0009-0003-1708-9646, Henny |
| author_facet | Hendiyani Irjanti 0009-0003-1708-9646, Henny |
| contents | <p>This manuscript presents the <strong>Microbial Enzymatic Cycle (MEC)</strong> as a unifying framework for human physiology, positioning microbial metabolism as an upstream driver of redox balance, structural integrity, and physiological directionality.</p> <p>MEC integrates three interdependent microbial enzymatic systems—<strong>C1 metabolism</strong>, the <strong>acetate–acetyl-CoA cycle</strong>, and the <strong>nitrogen–amino acid cycle</strong>—into a single operational architecture that precedes and shapes cellular, organ-level, and system-wide function. Through this framework, physiological states are understood as <strong>directional outcomes</strong> (regenerative versus degenerative) emerging from microbial redox coherence rather than isolated cellular or genetic processes.</p> <p>The manuscript further demonstrates how microbial enzymatic outputs converge within the <strong>extracellular matrix (ECM) and fascia network</strong>, translating biochemical activity into biophysical structure, signal distribution, and systemic coordination. This integration provides mechanistic explanations for phenomena insufficiently addressed by existing SCFA-centric, immune-centric, neurotransmitter-based, or systems biology models.</p> <p>Finally, the paper introduces the concept of <strong>biochemical directionality</strong>, formalized as Green (regenerative) and Orange (degenerative) loops, and situates emotional and neurophysiological regulation as valid modulators of microbial redox coherence within the MEC framework.</p> <p>Together, MEC offers a <strong>distinct biological category</strong> that reframes human physiology as an ecological, enzyme-driven architecture, with implications for regenerative medicine, systems biology, and integrative health research.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17928465 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Microbial Enzymatic Cycle (MEC) & The Origin of Physiological Architecture: A Mechanistic Foundation for the Microbial Integration Theory (MIT) Hendiyani Irjanti 0009-0003-1708-9646, Henny Microbiota/physiology Gastrointestinal Microbiome Gastrointestinal Microbiome/physiology Microbiota/immunology Microbial Enzymatic Cycle (MEC) Microbiome–host integration Redox biology Extracellular matrix (ECM) Fascia network Metabolic directionality Systems physiology Regenerative versus degenerative states <p>This manuscript presents the <strong>Microbial Enzymatic Cycle (MEC)</strong> as a unifying framework for human physiology, positioning microbial metabolism as an upstream driver of redox balance, structural integrity, and physiological directionality.</p> <p>MEC integrates three interdependent microbial enzymatic systems—<strong>C1 metabolism</strong>, the <strong>acetate–acetyl-CoA cycle</strong>, and the <strong>nitrogen–amino acid cycle</strong>—into a single operational architecture that precedes and shapes cellular, organ-level, and system-wide function. Through this framework, physiological states are understood as <strong>directional outcomes</strong> (regenerative versus degenerative) emerging from microbial redox coherence rather than isolated cellular or genetic processes.</p> <p>The manuscript further demonstrates how microbial enzymatic outputs converge within the <strong>extracellular matrix (ECM) and fascia network</strong>, translating biochemical activity into biophysical structure, signal distribution, and systemic coordination. This integration provides mechanistic explanations for phenomena insufficiently addressed by existing SCFA-centric, immune-centric, neurotransmitter-based, or systems biology models.</p> <p>Finally, the paper introduces the concept of <strong>biochemical directionality</strong>, formalized as Green (regenerative) and Orange (degenerative) loops, and situates emotional and neurophysiological regulation as valid modulators of microbial redox coherence within the MEC framework.</p> <p>Together, MEC offers a <strong>distinct biological category</strong> that reframes human physiology as an ecological, enzyme-driven architecture, with implications for regenerative medicine, systems biology, and integrative health research.</p> |
| title | Microbial Enzymatic Cycle (MEC) & The Origin of Physiological Architecture: A Mechanistic Foundation for the Microbial Integration Theory (MIT) |
| topic | Microbiota/physiology Gastrointestinal Microbiome Gastrointestinal Microbiome/physiology Microbiota/immunology Microbial Enzymatic Cycle (MEC) Microbiome–host integration Redox biology Extracellular matrix (ECM) Fascia network Metabolic directionality Systems physiology Regenerative versus degenerative states |
| url | https://doi.org/10.5281/zenodo.17928465 |