Therapeutic targeting in HER2+ breast cancer to prevent and treat CNS disease: ADGRF1.
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Zenodo
2025
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| _version_ | 1866901624977358848 |
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| author | Mamoor, Shahan |
| author_facet | Mamoor, Shahan |
| contents | <p dir="ltr">Up to 50% of patients with HER2+ subtype breast cancer develop metastasis to the central nervous system, most commonly the brain, demanding rapid therapeutic approaches to limit spread of the HER2+ primary tumor to distant sites (1-3). We recently described the existence of a group of genes that reside proximal to ERBB2 (the gene that encodes the human epidermal growth factor HER2) at 17q12: their differential expression in HER2+ breast cancer, their up-regulation in HER2+ breast cancer, their differential expression and up-regulation in central nervous system (CNS) metastasis and, based on human survival studies, their function in supporting metastasis to the CNS, indicating that the predilection of HER2+ patients to develop CNS metastasis was a phenomena attributable to the disease and not HER2+-targeted therapies (4). Disease recurrence following disease remission (relapse), resistance to trastuzumab or otherwise inadequate long-term control of disease are challenges that limit effectiveness of existing HER2+-targeted therapies. We utilized whole transcriptome technologies (5, 6) to measure total transcription in the primary tumors of humans with HER2+ breast cancer, identifying genes in the HER2 signature based on difference from the luminal A and luminal B tumor transcriptomes. We describe here a candidate therapeutic target up-regulated and differentially expressed in human HER2+ breast cancer, ADGRF1, as a candidate therapeutic target for the prevention and management of CNS metastasis in HER2+ breast cancer. </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17942608 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Therapeutic targeting in HER2+ breast cancer to prevent and treat CNS disease: ADGRF1. Mamoor, Shahan <p dir="ltr">Up to 50% of patients with HER2+ subtype breast cancer develop metastasis to the central nervous system, most commonly the brain, demanding rapid therapeutic approaches to limit spread of the HER2+ primary tumor to distant sites (1-3). We recently described the existence of a group of genes that reside proximal to ERBB2 (the gene that encodes the human epidermal growth factor HER2) at 17q12: their differential expression in HER2+ breast cancer, their up-regulation in HER2+ breast cancer, their differential expression and up-regulation in central nervous system (CNS) metastasis and, based on human survival studies, their function in supporting metastasis to the CNS, indicating that the predilection of HER2+ patients to develop CNS metastasis was a phenomena attributable to the disease and not HER2+-targeted therapies (4). Disease recurrence following disease remission (relapse), resistance to trastuzumab or otherwise inadequate long-term control of disease are challenges that limit effectiveness of existing HER2+-targeted therapies. We utilized whole transcriptome technologies (5, 6) to measure total transcription in the primary tumors of humans with HER2+ breast cancer, identifying genes in the HER2 signature based on difference from the luminal A and luminal B tumor transcriptomes. We describe here a candidate therapeutic target up-regulated and differentially expressed in human HER2+ breast cancer, ADGRF1, as a candidate therapeutic target for the prevention and management of CNS metastasis in HER2+ breast cancer. </p> |
| title | Therapeutic targeting in HER2+ breast cancer to prevent and treat CNS disease: ADGRF1. |
| url | https://doi.org/10.5281/zenodo.17942608 |