Natural Interventions for Asthma: The Evolving Role of Nutraceuticals in Respiratory Care
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2025
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| author | Sanchita Das, Ankan Ghosh, Supriya Changdar, Soumen Kanti Mondal, Krishnendu Dakua, Pradip Nandi, Supriya Hazra, Tourin Rahaman, Sumit Prasad Bhakat |
| author_facet | Sanchita Das, Ankan Ghosh, Supriya Changdar, Soumen Kanti Mondal, Krishnendu Dakua, Pradip Nandi, Supriya Hazra, Tourin Rahaman, Sumit Prasad Bhakat |
| contents | <p>Asthma is a chronic inflammatory airway disease characterized by reversible airflow obstruction, <br>bronchial hyperresponsiveness, and airway remodelling. Despite advances in pharmacotherapy, <br>incomplete symptom control, steroid resistance, and adverse effects persist, creating a need for <br>complementary approaches. Nutraceuticals—bioactive compounds derived from food—offer both <br>nutritional and pharmacological benefits that target key mechanisms such as oxidative stress, inflammation, <br>and immune imbalance in asthma. This review explores the therapeutic role of major nutraceuticals <br>including omega-3 fatty acids, vitamin D, and curcumin, along with antioxidants and herbal agents such as <br>Nigella sativa, saffron, and Adhatoda vasica. These compounds modulate inflammatory mediators (IL-4, <br>IL-5, TNF-α), inhibit NF-κB and STAT3 pathways, enhance antioxidant defenses, and reduce airway <br>hyperresponsiveness. Clinical studies demonstrate improvements in lung function and symptom control, <br>though results vary due to differences in formulations and dosages. Furthermore, pharmacists play a vital <br>role in educating patients about appropriate nutraceutical use, potential interactions, and their adjunctive <br>nature alongside conventional therapies. While nutraceuticals are not replacements for standard asthma <br>medications, they represent a promising integrative strategy to improve respiratory health, minimize <br>inflammation, and enhance quality of life when used under professional guidance. </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_17972575 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
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| spellingShingle | Natural Interventions for Asthma: The Evolving Role of Nutraceuticals in Respiratory Care Sanchita Das, Ankan Ghosh, Supriya Changdar, Soumen Kanti Mondal, Krishnendu Dakua, Pradip Nandi, Supriya Hazra, Tourin Rahaman, Sumit Prasad Bhakat <p>Asthma is a chronic inflammatory airway disease characterized by reversible airflow obstruction, <br>bronchial hyperresponsiveness, and airway remodelling. Despite advances in pharmacotherapy, <br>incomplete symptom control, steroid resistance, and adverse effects persist, creating a need for <br>complementary approaches. Nutraceuticals—bioactive compounds derived from food—offer both <br>nutritional and pharmacological benefits that target key mechanisms such as oxidative stress, inflammation, <br>and immune imbalance in asthma. This review explores the therapeutic role of major nutraceuticals <br>including omega-3 fatty acids, vitamin D, and curcumin, along with antioxidants and herbal agents such as <br>Nigella sativa, saffron, and Adhatoda vasica. These compounds modulate inflammatory mediators (IL-4, <br>IL-5, TNF-α), inhibit NF-κB and STAT3 pathways, enhance antioxidant defenses, and reduce airway <br>hyperresponsiveness. Clinical studies demonstrate improvements in lung function and symptom control, <br>though results vary due to differences in formulations and dosages. Furthermore, pharmacists play a vital <br>role in educating patients about appropriate nutraceutical use, potential interactions, and their adjunctive <br>nature alongside conventional therapies. While nutraceuticals are not replacements for standard asthma <br>medications, they represent a promising integrative strategy to improve respiratory health, minimize <br>inflammation, and enhance quality of life when used under professional guidance. </p> |
| title | Natural Interventions for Asthma: The Evolving Role of Nutraceuticals in Respiratory Care |
| url | https://doi.org/10.5281/zenodo.17972575 |