Formulation and Characterization of Risperidone Sustained Release Buccal Tablets using Natural Polymers
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2025
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| author | Shivani Yadav*, Dr. Avinash Kondalkar, Narottam Singh, Muraree Lal, Shankar |
| author_facet | Shivani Yadav*, Dr. Avinash Kondalkar, Narottam Singh, Muraree Lal, Shankar |
| contents | <p><span>The study successfully developed Risperidone-loaded buccal tablets capable of providing sustained drug delivery using a combination of HPMC K4M and Carbopol polymers. Comprehensive physicochemical evaluation confirmed the identity, purity, and stability of Risperidone. Pre-compression and post-compression parameters demonstrated that all formulations possessed acceptable flow properties, mechanical strength, and uniformity. Swelling studies highlighted the importance of polymer ratio in controlling hydration and drug release behavior. Among the six formulations, F5 exhibited superior swelling, optimal mucoadhesive potential, and sustained drug release over 12 hours. Kinetic modelling further confirmed that the optimized formulation F5 followed First-order kinetics with a non-Fickian diffusion mechanism, indicating that both polymer swelling and diffusion processes governed the drug release. The sustained release profile and excellent physicochemical properties of F5 demonstrate its potential as an effective buccal delivery system for Risperidone, offering improved therapeutic compliance, avoidance of first-pass metabolism, and a promising alternative to conventional oral dosage forms.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18000773 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
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| spellingShingle | Formulation and Characterization of Risperidone Sustained Release Buccal Tablets using Natural Polymers Shivani Yadav*, Dr. Avinash Kondalkar, Narottam Singh, Muraree Lal, Shankar Risperidone, Buccal tablets, Direct compression, HPMC K4M, Carbopol, Swelling index, Mucoadhesive polymers, In-vitro drug release, Kinetic modeling, First-order kinetics <p><span>The study successfully developed Risperidone-loaded buccal tablets capable of providing sustained drug delivery using a combination of HPMC K4M and Carbopol polymers. Comprehensive physicochemical evaluation confirmed the identity, purity, and stability of Risperidone. Pre-compression and post-compression parameters demonstrated that all formulations possessed acceptable flow properties, mechanical strength, and uniformity. Swelling studies highlighted the importance of polymer ratio in controlling hydration and drug release behavior. Among the six formulations, F5 exhibited superior swelling, optimal mucoadhesive potential, and sustained drug release over 12 hours. Kinetic modelling further confirmed that the optimized formulation F5 followed First-order kinetics with a non-Fickian diffusion mechanism, indicating that both polymer swelling and diffusion processes governed the drug release. The sustained release profile and excellent physicochemical properties of F5 demonstrate its potential as an effective buccal delivery system for Risperidone, offering improved therapeutic compliance, avoidance of first-pass metabolism, and a promising alternative to conventional oral dosage forms.</span></p> |
| title | Formulation and Characterization of Risperidone Sustained Release Buccal Tablets using Natural Polymers |
| topic | Risperidone, Buccal tablets, Direct compression, HPMC K4M, Carbopol, Swelling index, Mucoadhesive polymers, In-vitro drug release, Kinetic modeling, First-order kinetics |
| url | https://doi.org/10.5281/zenodo.18000773 |