Analytical Method Development and Validation of Selexipag by different quantitative Analytical Techniques
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2025
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| author | C. Sushma L Sivasanker Reddy S Gejalakshmi R. Nageswara Rao |
| author_facet | C. Sushma L Sivasanker Reddy S Gejalakshmi R. Nageswara Rao |
| contents | <p>Selexipag, a selective prostacyclin IP receptor agonist, is used for the treatment of pulmonary arterial hypertension (PAH). Analytical methods such as reversed-phase high-performance liquid chromatography (RP-HPLC), ultraviolet-visible (UV) spectroscopy, and their combination (RP-HPLCUV) are critical for the accurate quantification and quality control of selexipag in bulk and pharmaceutical formulations. This review comprehensively discusses the development, optimization, and validation of RPHPLC, UV, and RP-HPLC-UV methods for selexipag, focusing on their principles, applications, and compliance with International Conference on Harmonization (ICH) guidelines. Recent advancements, challenges, and future perspectives in these analytical techniques are also highlighted.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18052898 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
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| spellingShingle | Analytical Method Development and Validation of Selexipag by different quantitative Analytical Techniques C. Sushma L Sivasanker Reddy S Gejalakshmi R. Nageswara Rao <p>Selexipag, a selective prostacyclin IP receptor agonist, is used for the treatment of pulmonary arterial hypertension (PAH). Analytical methods such as reversed-phase high-performance liquid chromatography (RP-HPLC), ultraviolet-visible (UV) spectroscopy, and their combination (RP-HPLCUV) are critical for the accurate quantification and quality control of selexipag in bulk and pharmaceutical formulations. This review comprehensively discusses the development, optimization, and validation of RPHPLC, UV, and RP-HPLC-UV methods for selexipag, focusing on their principles, applications, and compliance with International Conference on Harmonization (ICH) guidelines. Recent advancements, challenges, and future perspectives in these analytical techniques are also highlighted.</p> |
| title | Analytical Method Development and Validation of Selexipag by different quantitative Analytical Techniques |
| url | https://doi.org/10.5281/zenodo.18052898 |